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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Clin Gastroenterol Hepatol. 2022 Dec 17;21(3):604–616. doi: 10.1016/j.cgh.2022.12.008

Table 3:

Colorectal Cancer Screening Test Type Strengths and Weaknesses

Screening Test Sensitivity/Specificity for Cancer Sensitivity/Specificity for Advanced Adenomas Convenience Safety Cost
FIT +++ + +++ ++++ +
Colonoscopy ++++ ++++ + ++ ++++
Stool DNA +++ ++ +++ ++++ ++
Stool RNA +++ ++ +++ ++++ ?
ct DNA +++ +/? ++++ ++++ ++/?
Serum proteome ++/? ? ++++ ++++ ++/?
Microbiome +++/? ? ++++ ++++ ?

?=insufficient data at this time to determine reliably