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. Author manuscript; available in PMC: 2024 Feb 23.
Published in final edited form as: J Med Chem. 2023 Jan 23;66(4):2979–3009. doi: 10.1021/acs.jmedchem.2c01996

Table 7.

Pharmacokinetics of G1 in rats following intravenous and oral administration (n = 3).

Parameter G1
(n = 3)
G1
(n = 3)
iv (10 mg / kg) po (50 mg / kg)
Tmax(h) 0.03 0.25
Cmax(nM) 3.77 2.92
t1/2(h) 5.72 5.55
CL(L / h / kg) 0.29 1.70
VZ(L / kg) 2.39 13.12
AUC(0–8) (nM∙h) 6.13 6.39
AUC(0−∞) (nM∙h) 11.47 10.15
F (%) 20.85