Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 28;14:1128. doi: 10.1038/s41467-023-36800-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Overview of NeuronChat database. NeuronChat database includes ligand-target pairs required for chemical synapse, electrical synapse and synaptic adhesion (left panel). There are a total of 373 ligand-target pairs for both human and mouse, curated into five categories based on the type of the ligand (middle panel). The interaction pair list includes the ligand, target, and genes contributing to them (right panel). Note that genes contributing to the ligand are categorized into different groups (indicated by colors) based on their biological functions such as synthesis or vesicular transport. b Schematic diagram to illustrate the computational model of NeuronChat. The communication strength characterizes the coordinated expression of genes required for ligand emission in the sender cell group, and the expression of the target gene in the receiver cell group. The statistical significance of a communication link is determined by the permutation test (* and ns represent significant and not significant, respectively). Only significant links are kept in the output communication strength matrix while values for not significant links are set to be zeros. See Methods for details. c Functionalities of NeuronChat: visualization and analysis of the intercellular communication networks, making systemic comparisons across different biological contexts, and multi-layered visualization for spatial transcriptomics.