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. 2023 Feb 28;14:1128. doi: 10.1038/s41467-023-36800-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Comparison of the number (left panel) and weight (right panel) of all the links inferred between ASD and control. b Circle plots showing the upregulated (upper panel) and downregulated (lower panel) intercellular communications in ASD compared to control. The width of each link indicates the absolute difference between ASD and control, in the sum of communication strength values over all interaction pairs. c Heatmap showing the differential outgoing (upper panel) and incoming (lower panel) signal strength between ASD and control. Given the cell group and interaction pair, the outgoing (or incoming) signal strength is defined as the sum of communication strength over the links from (or to) the cell group. The color bar indicates the difference in the outgoing (or incoming) signal strength values between ASD and control. d Bar charts comparing the number of links (left) and information flow (right) between ASD and control for each interaction pair. e Projecting interactions onto a two-dimensional manifold according to their functional similarity (upper panel) and magnified view of each interaction group (lower panel). Each interaction pair is represented by a circle (for ASD) or triangle (for control), whose color and size indicate the functional group and total communication strength (normalized by the maximum), respectively.