Table 4.
Examination of an association between baseline BMP concentrations and longitudinal changes in DaT, MoCA or MDS-UPDRS III off.
| Variant | Effect | Estimate | 95% CI | P value | |
|---|---|---|---|---|---|
| a Baseline BMP concentrations are not associated with longitudinal change in mean striatal DaT SBR | |||||
| G2019S+ | Total di-18:1-BMP*time | 0.00001 | −0.0001 | 0.0001 | 0.7806 |
| Total di-22:6-BMP*time | 0.00001 | −0.00002 | 0.00003 | 0.6726 | |
| 2,2’ di-22:6-BMP*time | 0.000002 | −0.00003 | 0.00003 | 0.8718 | |
| R1441G+ | Total di-18:1-BMP*time | 0.0003 | −0.000002 | 0.0007 | 0.0512 |
| Total di-22:6-BMP*time | −0.0001 | −0.0002 | 0.0001 | 0.3025 | |
| 2,2’ di-22:6-BMP*time | −0.0001 | −0.0003 | 0.0001 | 0.3199 | |
| N409S+ | Total di-18:1-BMP*time | 0.00005 | −0.0003 | 0.0004 | 0.7988 |
| Total di-22:6-BMP*time | 0.00008 | −0.00008 | 0.0002 | 0.3231 | |
| 2,2’ di-22:6-BMP*time | 0.0001 | −0.0001 | 0.0003 | 0.3074 | |
| sPD* | Total di-18:1-BMP*time | 0.00004 | −0.00008 | 0.0002 | 0.4884 |
| Total di-22:6-BMP*time | 0.000003 | −0.00005 | 0.00005 | 0.9157 | |
| 2,2’ di-22:6-BMP*time | −0.000004 | −0.00007 | 0.00007 | 0.9208 | |
| b Baseline BMP concentrations are not associated with longitudinal change in MoCA. | |||||
|---|---|---|---|---|---|
| G2019S+ | Total di-18:1-BMP*time | −0.0001 | −0.0005 | 0.0002 | 0.4543 |
| Total di-22:6-BMP*time | −0.00004 | −0.0002 | 0.0001 | 0.5437 | |
| 2,2’ di-22:6-BMP*time | −0.00002 | −0.0002 | 0.0001 | 0.8290 | |
| R1441G+ | Total di-18:1-BMP*time | 0.0022 | 0.0001 | 0.0044 | 0.0418 |
| Total di-22:6-BMP*time | −0.0003 | −0.0010 | 0.0004 | 0.3532 | |
| 2,2’ di-22:6-BMP*time | −0.0005 | −0.0013 | 0.0003 | 0.2060 | |
| N409S+ | Total di-18:1-BMP*time | 0.0006 | −0.0011 | 0.0023 | 0.4694 |
| Total di-22:6-BMP*time | 0.0002 | −0.0006 | 0.0009 | 0.6190 | |
| 2,2’ di-22:6-BMP*time | 0.0003 | −0.0007 | 0.0013 | 0.5618 | |
| sPD and HC | Total di-18:1-BMP*time | −0.0011 | −0.0019 | −0.0002 | 0.0108 |
| Total di-22:6-BMP*time | −0.0002 | −0.0005 | 0.0001 | 0.1796 | |
| 2,2’ di-22:6-BMP*time | −0.0003 | −0.0007 | 0.0001 | 0.1554 | |
| c Baseline BMP concentrations are not associated with longitudinal change in MDS-UPDRS III Off. | |||||
|---|---|---|---|---|---|
| G2019S+ | Total di-18:1-BMP*time | 0.0002 | −0.0019 | 0.0024 | 0.8273 |
| Total di-22:6-BMP*time | −0.0004 | −0.0012 | 0.0004 | 0.3223 | |
| 2,2’ di-22:6-BMP*time | −0.0005 | −0.0014 | 0.0004 | 0.3022 | |
| R1441G+ | Total di-18:1-BMP*time | 0.0077 | −0.0021 | 0.0176 | 0.1186 |
| Total di-22:6-BMP*time | −0.0037 | −0.0070 | −0.0004 | 0.0314 | |
| 2,2’ di-22:6-BMP*time | −0.0039 | −0.0079 | 0.0002 | 0.0591 | |
| N409S+ | Total di-18:1-BMP*time | −0.0003 | −0.0105 | 0.0099 | 0.9495 |
| Total di-22:6-BMP*time | 0.0008 | −0.0039 | 0.0055 | 0.7496 | |
| 2,2’ di-22:6-BMP*time | 0.0002 | −0.0060 | 0.0064 | 0.9457 | |
| sPD and HC | Total di-18:1-BMP*time | 0.0009 | −0.0027 | 0.0046 | 0.6230 |
| Total di-22:6-BMP*time | 0.0002 | −0.0011 | 0.0016 | 0.7492 | |
| 2,2’ di-22:6-BMP*time | 0.0003 | −0.0015 | 0.0021 | 0.7462 | |