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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Immunology. 2022 Nov 2;168(3):554–568. doi: 10.1111/imm.13594

Figure 2. mTORC2 in T cells is required for B cell hyper-activation in Lpr mice.

Figure 2.

(A) Immunofluorescence staining of peanut agglutinin (PNA), CD3 and IgD on spleen sections from 6 months old B6, Lpr and Lpr.Rictor T-KO mice. (B) Flow cytometry analysis of GL-7 and IgD expression among B220+TCRβ– cells. Right, the frequency of IgD–GL-7+ germinal center (GC) B cells. (C) Immunofluorescence staining of CD138 and IgD on spleen sections from 6 months old B6, Lpr and Lpr.Rictor T-KO mice. (D) Flow cytometry analysis of B220+CD138int and B220loCD138hi two populations. Right, the frequencies of B220+CD138int (left) and B220loCD138hi (right) among total lymphocytes. (B) and (D) Cells were from pLNs of 6 months old B6, Lpr and Lpr.Rictor T-KO mice. NS, not significant; *** P < 0.001, **** P < 0.0001 (one-way ANOVA). Results were pooled from 3 (B and D) independent experiments. Error bars represent SEM.