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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Dec 29;43(3):388–398. doi: 10.1161/ATVBAHA.122.317966

Figure 1. Regulation of lipolysis:

Figure 1.

VLDL (and chylomicrons) lose much of their core lipids due to lipolysis in the circulation. The initial step in this process is mediated by lipoprotein lipase (LPL). LPL is synthesized in myocytes and adipocytes and requires the presence of lipase maturation factor 1 (LMF1) for secretion. LPL actions require its transport to the luminal endothelial cell surface in association with glycosylphosphotidylinositol anchored HDL binding protein, which also maintains LPL in an active form on the endothelial cells. LPL activity only occurs in the presence of a co-factor APOC2. LPL is inhibited by APOC3 and the complexes ANGPTL3/8 and ANGPTL4/8. APOA5 may prevent LPL inactivation by ANGPTL3/8.