Figure 2.

Genomic profiling of LCO samples

(A) The overlap of somatic alteration in effusion and LCO samples. Blue indicates alterations detected from both sources, pink indicates alterations that were present only in the effusion samples, and scarlet indicates alterations were present only in the LCO samples. See also Figures S2A and S2B, and Tables S1 and S2.

(B) The difference of maxAF between effusion and LCO samples.

(C) The concordance for somatic alterations between effusion and LCO samples.

(D) The difference of TMB between effusion and LCO samples. p values are determined using the two-tailed t-test or Mann–Whitney U test for continuous variables.

(E) Correlation between effusion-based and LCO-based TMB (Pearson correlation coefficient, two-tailed). ADC, adenocarcinoma; ASC, adenosquamous carcinoma; CN, copy number; F, female; Indel, small insertion and deletion; LCO, lung cancer organoid; LGR, large genomic rearrangements; M, male; maxAF, maximum allele frequency; MSE, malignant serous effusion; SCC, squamous cell carcinoma; TMB, tumor mutational burden.