Fig. 1. Subjects were randomly assigned to the InsP6-diet group or to the non-InsP6-diet group for 12 weeks.

After 12 weeks, each group was given a 12-week washout period, and then switched to the alternate diet for 12 weeks. All patients were then followed for an additional 12 weeks. Patients received an InsP6 diet (diet plan with InsP6 supplementation) or a non-InsP6 diet (the same diet plan without InsP6 supplementation). Blood test, urine samples, food frequency questionnaire, clinical histories, and physical and anthropometric measurements were prospectively collected during the trial.