Table 1.
Baseline participant characteristics by categories of elevated hs-cTnT and low ABI.
| Characteristics | All participants (N = 10,897) |
hs-cTnT (<14 ng/L) & ABI (0.9 – 1.4) (n = 9206) | hs-cTnT (≥14 ng/L) & ABI (0.9 – 1.4) (n = 876) |
hs-cTnT (<14 ng/L) & ABI (<0.9) (n = 577) |
hs-cTnT (≥14 ng/L) & ABI (<0.9) (n = 238) |
|---|---|---|---|---|---|
| Age in years, mean(SD) | 66.3(10.1) | 64.9(9.9) | 73.1(8.4) | 73.1(7.4) | 76.6(7.2) |
| Male (%) | 44.7 | 42.1 | 70.8 | 37.8 | 68.1 |
| Race/Ethnicity (%) | |||||
| White | 55.9 | 54.9 | 61.0 | 60.5 | 61.8 |
| Black | 23.2 | 21.8 | 29.7 | 33.1 | 31.1 |
| Hispanic | 13.4 | 14.8 | 6.7 | 3.8 | 5.0 |
| Asian | 7.3 | 8.3 | 1.7 | 1.9 | 1.3 |
| Other race | 0.3 | 0.2 | 0.9 | 0.7 | 0.8 |
| Pack years of smoking | 13.7(23.6) | 12.4(22.3) | 17.6(27.4) | 25.1(29.9) | 21.1(29.4) |
| Alcohol (drinks/week) | 2.4(6.1) | 2.4(5.6) | 2.3(5.8) | 2.6(11.4) | 2.2(5.4) |
| Exercise (met-hr/wk) | 27.1(37.2) | 27.9(38.1) | 26.3(35.6) | 19.2(28.0) | 18.9(25.7) |
| BMI (kg/m2) | 27.7(5.2) | 27.7(5.2) | 27.9(5.1) | 26.8(5.1) | 26.5(4.7) |
| eGFR (ml/min/1.73m2) | 80.1(19.1) | 81.8(18.1) | 68.2(20.7) | 76.5(20) | 59.3(22.1) |
| Total cholesterol (mg/dL) | 201.0(37.9) | 201.0(37.1) | 193.6(40.8) | 211.6(42.8) | 202.3(40.1) |
| HDL cholesterol (mg/dL) | 52.3(15.3) | 52.6(15.1) | 49.9(16) | 52.2(16) | 49.6(16.8) |
| Triglycerides (mg/dL)] | 135.0(85.9) | 133.7(81.6) | 142.8(120.8) | 139.0(74.8) | 146.8(111.6) |
| Hypertension (%) | 55.5 | 51.3 | 76.6 | 76.6 | 89.9 |
| Diabetes mellitus (%) | 14.3 | 11.8 | 29.0 | 24.2 | 34.5 |
| Antihypertensives (%) | 41.3 | 37.7 | 58.9 | 56.7 | 75.2 |
| Statins (%) | 9.9 | 10.0 | 8.9 | 10.7 | 6.7 |
| Family history of CHD (%) | 38.6 | 38.8 | 33.7 | 42.3 | 37.8 |
| Family history of ASCVD (%) | 51.7 | 52.3 | 45.5 | 52.9 | 49.3 |
| ABI† | 1.1(0.1) | 1.1(0.1) | 1.1(0.1) | 0.7(0.1) | 0.7(0.1) |
| hs-cTnT (ng/L)† | 7.6(18.5) | 5.3(2.8) | 25.6(32.5) | 6.8(3.4) | 35.1(96.7) |
Abbreviations: ABI, ankle-brachial index; ASCVD, Atherosclerotic cardiovascular disease; BMI, body mass index; CHD, coronary heart disease; eGFR, estimated glomerular filtration rate; HDL, high density lipoprotein; hs-cTnT, highly-sensitive cardiac troponin; MET, Metabolic Equivalent of Task; SD, standard deviation. †Median (interquartile range) for hs-cTnT 4.7(2.99–8.46) and for ABI 1.1(1.0–1.2). * p-value is from a one-way anova comparing characteristics across categories of hs-cTnT and ABI.