Table 3.
Stratified analysis of highly-sensitive cardiac troponin-T and ankle-brachial index with cardiovascular events in a Cox proportional hazards model.
| Outcome CHD |
Outcome ASCVD |
|||||
|---|---|---|---|---|---|---|
| Incidence rate (100 person-years) | Adjusted HR (95% CI) | p-value | Incidence rate (100 person-years) | Adjusted HR (95% CI) | p-value | |
| Stratified analysis | ||||||
| Non-elevated hs-cTnT (<14 ng/L) | ||||||
| Normal ABI (0.9 - 1.4) | 0.97 | 1 (reference) | 1.73 | 1 (reference) | ||
| Low ABI (<0.9) | 2.61 | 1.85 (1.50, 2.28) | <0.001 | 4.43 | 1.67 (1.41, 1.97) | <0.001 |
| Elevated (≥14 ng/L) | ||||||
| Normal ABI (0.9 - 1.4) | 2.73 | 1 (reference) | 4.59 | 1 (reference) | ||
| Low ABI (<0.9) | 4.15 | 1.15 (0.79, 1.68) | 0.47 | 7.32 | 1.22 (0.92, 1.64) | 0.17 |
| Normal ABI (0.9 - 1.4) | ||||||
| Non-elevated hs-cTnT (<14 ng/L) | 0.97 | 1 (reference) | 1.73 | 1 (reference) | ||
| Elevated (≥14 ng/L) | 2.73 | 1.62 (1.34, 1.96) | <0.001 | 4.59 | 1.64 (1.41, 1.90) | <0.001 |
| Low ABI (<0.9) | ||||||
| Non-elevated hs-cTnT (<14 ng/L) | 2.61 | 1 (reference) | 4.43 | 1 (reference) | ||
| Elevated (≥14 ng/L) | 4.15 | 1.29 (0.82, 2.02) | 0.27 | 7.32 | 1.31 (0.93, 1.84) | 0.13 |
| Model output | ||||||
| Elevated (≥14 ng/L) vs. non-elevated (<14 ng/L) hs-cTnT | 1.65 (1.37, 1.99) | <0.001 | 1.67 (1.44, 1.93) | <0.001 | ||
| Low (<0.9) vs. normal (0.9 - 1.4) ABI | 1.87 (1.52, 2.31) | <0.001 | 1.67 (1.42, 1.97) | <0.001 | ||
| Interaction term of elevated (≥14 ng/L) and low ABI | 0.66 (0.44, 0.99) | 0.046 | 0.73 (0.54, 1.01) | 0.06 | ||
Abbreviations: ABI, ankle-brachial index; ASCVD, Atherosclerotic cardiovascular disease; hs-cTnT, highly-sensitive cardiac troponin-T; CHD, coronary heart disease; CI, confidence interval; HR, hazard ratio.
Models were adjusted for age (years), sex (male, female), race/ethnicity (White, Black, Hispanic, Asian, other), education (<high school, high school complete, some college, college complete, graduate), pack years of smoking (continuous), alcohol drinks/week (continuous), exercise (met-hr/wk continuous), body mass index (continuous), hypertension (yes/no), diabetes (yes/no), glomerular filtration rate (continuous), total cholesterol (continuous), HDL cholesterol (continuous), triglyceride (continuous), hypertension medication (yes/no), statin (yes/no), family history of CVD (yes/no) and cohort indicator (MESA/CHS).