Figure 7.
Molecular subtype associations with drug response in cancer cell lines
(A) Transcriptional profiles of 958 cancer cell lines represented in the Genomics of Drug Sensitivity in Cancer (GDSC)29 dataset (profiles being normalized within their respective cancer type) were classified according to PDX-based molecular subtype. Expression patterns in cell lines for the top set of 800 mRNAs distinguishing between the four PDX-based subtypes (from Figure 1A) are shown (759 of the 800 genes being represented in GDSC).
(B) From the GDSC cell lines classified according to metastasis subtype, drug compound treatments with decreases in half-maximal inhibitory concentration (IC50) associated with s1, s3, or s4 subtypes (p < 0.001, comparing cell lines of the given subtype with the rest of the cell lines, t test on natural log-transformed IC50 values). Selected drug compounds are listed by name.
(C) For selected drug compounds, natural log IC50s by molecular subtype. Boxplots represent 5% (lower whisker), 25% (lower box), 50% (median), 75% (upper box), and 95% (upper whisker). Data points are colored according to cancer type, according to color coding in (A).