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. 2023 Feb 7;4(2):100934. doi: 10.1016/j.xcrm.2023.100934

Figure 2.

Figure 2

Several differentiation statuses were identified based on the cellular diversity within APGs

(A) Partition-based graph abstraction connectivity among clusters of PIT1 lineage cells in APGs based on velocity-inferred directionality.

(B) Integrated UMAP plot of PIT1 lineage cells from APGs with cells colored by Monocle3-inferred pseudotime.

(C) Gene expression trends in particular genes along the differentiation trajectory from Pro.PIT1 toward SOMATO and LACTOHigh.

(D) Integrated UMAP plot and Slingshot developmental trajectories of integrated adult and fetal APGs with cells colored according to the corresponding cell type.

(E) mIHC staining of GH, NTS, PIT1, PRL, ENPP1, and TSHB in sections from adult APGs. Tissues were counterstained with DAPI. Scale bars, 50 μm

(F) mIHC staining of GH, IGFBP7, PRL, LRRC4C, PIT1, and TSHB in sections from adult APGs. Tissues were counterstained with DAPI. Scale bars, 50 μm. See also Figure S3.