Table 2.

Univariate analysis of factors associated with first-generation EGFR-TKI clinical responses.

Factor	N (%)	HR for PFS	P value
Gender (female)	27 (54.0)	1.08 (0.60∼1.93)	0.805
Age (≥60)	21 (42.0)	1.25 (0.69∼2.26)	0.464
EGFR mutation subtype (uEGFR)	6 (12.0%)	2.51 (1.01∼6.21)	0.039
Signaling pathways
Cell cycle	9 (18.0)	0.58 (0.28∼1.24)	0.157
Hippo	2 (4.0)	2.66 (0.61∼11.52)	0.175
Myc	3 (6.0)	0.74 (0.22∼2.51)	0.627
Notch	4 (8.0)	0.97 (0.30∼3.16)	0.961
PI3K	11 (22.0)	2.21 (1.00∼4.93)	0.047
TGFβ	3 (6.0)	0.22 (0.05∼0.94)	0.028
p53	38 (76.0)	1.50 (0.75∼3.00)	0.244
Wnt	9 (18.0)	1.32 (0.60∼2.88)	0.484

Bold represents statistically significant P values based on the log-rank test.