Table 1. Prevalence estimates for chronic hepatitis B virus (HBV) infection in sub-populations in the United Kingdom.
| Estimate source | Population and/or data
source (study period/year) |
Sources and
citation(s) |
Estimate type | Denominator
(population tested) |
Number
of adults testing positive for HBV infection |
Percentage
infected with HBV in study/ survey population (%) |
Information
on relevant population characteristics † |
|---|---|---|---|---|---|---|---|
| PHE / UKHSA | Individuals tested
for HBsAg in 19 participating laboratories (excludes testing in antenatal services and reference lab testing; deduplicated using identifiers where available) (2020) |
Sentinel surveillance
of BBV testing 11 |
Positivity amongst
those tested (diagnosed prevalence) |
302,135 | 2611 | 0.86% | Yes: information
by ethnicity, sex, age, region |
|
Polaris
Observatory 12 |
Modelling study based on
literature review and expert interviews (2016) |
Razavi-Shearer
et al.,
2018 13 |
UK HBV population
prevalence |
2016 UK population of
65,648,000 14 |
440,000 | 0.73% | No |
|
PHE Infectious
Diseases in Pregnancy Screening Programme |
Pregnant women attending
antenatal services in England (April 2019-March 2020) |
Antenatal screening
standards data report 1 April 2019 – 31 March 2020 10, 15 |
Antenatal population
prevalence |
Pregnant women
attending antenatal services 661,281 (screening coverage of 99.8%) |
2493 | 0.38% | No |
| BLT 16 * | Source unavailable (likely
2002) § |
NICE guidelines 17, 18 ** | Number of people in
the UK positive for HBV - prevalence |
Not clearly stated
– likely 2002 UK population of 59,365,677 19 |
180,000 | 0.27% | No |
| CPRD | CPRD primary care database
consisting of EHRs from >16 million patients (2000 to 2015) |
Ferreira et al. 8 | Number of CHB
diagnoses in database |
CPRD subset of EHRs
from 4.4 million patients ¶ |
3927 | 0.09% | Yes |
|
QResearch
cohort 20 |
QResearch primary care
database (1999 to 2019) |
CCCC-UK cohort 7, 20 | Number of CHB
diagnoses in database |
QResearch database
subset of EHRs from 16.9 million patients 5 |
8039 | 0.05% | Yes |
HBV, Hepatitis B virus; UKHSA, United Kingdom Health Security Agency; PHE, Public Health England; PWID, people who inject drugs; BLT, British Liver Trust; NICE, National Institute for Health and Care Excellence; CPRD, Clinical Practice Research Datalink; CHB chronic Hepatitis B virus infection; EHR, electronic health record; CCCC, Characteristics of Chronic Hepatitis B associated with Cirrhosis and Cancer.
* The British Liver Trust published a HBV report in 2017 stating that approximately 180,000 people live with chronic HBV infection in the UK 16 . This report cited a governmental migrant health guide citing this prevalence estimate 17 . The source which this government report cited was a National Institute for Health and Care Excellence (NICE) testing guideline which stated this prevalence estimate and dated it to 2002 18 .
† May include but is not limited to: age, sex, ethnicity and socioeconomic status.
‡ Sources include “laboratory data and sentinel surveillance data” 11 .
§ Department of Health 2002 report cited 21 is unavailable for download. No clear methodology reported
¶ Subset of total (16.9 million) patients in CPRD with valid EHR information and temporality who were acceptable for research 8 .