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. 2023 Mar 1;23(1):71. doi: 10.1007/s10142-023-00998-1

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 4 — The PPI interaction network of specific genes and top 15 genes of five algorithms in severe COVID-19. A The PPI interaction network of severe specific genes. The red nodes represent up-regulated DEGs and the green nodes represent down-regulated DEGs. B The top 15 genes of five algorithms in severe cases