Table 1.
Patient demographics and clinical information
| Patient characteristic | Noncancer individuals n = 426 | Cancer patients n = 75 | P valuea |
|---|---|---|---|
| Age | |||
| Mean | 57.5 | 64.5 | <0.001 |
| Range | 27–81 | 38–88 | |
| Sex | |||
| Male | 235 | 63 | <0.001 |
| Female | 191 | 12 | |
| Liver disease | |||
| None | 293 | ||
| Hepatitis B | 26 | 1 | |
| Hepatitis C | 29 | 1 | |
| Cirrhosis | 78 | 69 | <0.001 |
| HCV | 53 | 41 | |
| HBV | 2 | 4 | |
| EtOH | 13 | 12 | |
| NAFLD | 3 | 11 | |
| Child–Pugh stage | |||
| A | 20 | 49 | <0.001 |
| B | 10 | 21 | |
| C | 10 | 5 | |
| Unknown | 38 | ||
| BCLC stage | |||
| 0 | 7 | ||
| A | 17 | ||
| B | 30 | ||
| C | 21 | ||
| Previous treatment | |||
| Yes | 28 | ||
| No | 47 | ||
| Validation cohort (Hong Kong) b | 133 | 90 | |
| Liver disease | |||
| None | 32 | ||
| Cirrhosis (HBV) | 35 | 90 | |
| Active HBV | 66 | ||
| BCLC stage | |||
| A | 85 | ||
| B | 5 | ||
Abbreviations: BCLC, Barcelona Clinic Liver Cancer staging system; EtOH, alcohol associated.
a P values were calculated to compare data from individuals with and without liver cancer for the following variables: mean ages using Student unpaired two-tailed t tests, sex distribution, cirrhosis etiology, and Child–Pugh stage using a χ2 test.
bValidation cohort data were obtained from Jiang et al. (15).