Table 2.
Top scoring TFs in US/EU cohort samples
| TF | Gene name | AUC | Cell type in ChIP-seq experiment | Gene function | Link to HCC |
|---|---|---|---|---|---|
| ZNF512 | Zinc Finger Protein 512 | 0.836 | K-562 | Unknown | Undescribed |
| ZNF184 | Zinc Finger Protein 184 | 0.826 | K-562 | Unknown | Undescribed |
| PCBP2 | Poly(C)-binding protein 2 | 0.791 | Hep-G2 | Transcriptional coregulator | Overexpression contributes to poor prognosis and enhanced cell growth in HCC (38) |
| JUN | Jun Proto-Oncogene, AP-1 Transcription Factor Subunit | 0.785 | Hep-G2 | TF | Promotes HBV-related liver tumorigenesis (59) |
| PHB2 | Prohibitin 2 | 0.771 | K-562 | Transcriptional coregulator | Functions in mitophagy of HCC (39) |
| ATF2 | Activating Transcription Factor 2 | 0.770 | Hep-G2 | TF, HAT | Mediates suppression of liver tumor formation (34) |
| ATF7 | Activating Transcription Factor 7 | 0.765 | MCF-7 | TF | Regulates growth of liver cancer (60) |
| TEAD4 | TEA Domain Transcription Factor 4 | 0.760 | Hep-G2 | TF | Oncogenic role in HCC (36) |
| ARID3A | AT-rich interacting domain 3A | 0.756 | Hep-G2 | TF | Facilitates liver cancer malignancy (40) |
| JUND | JunD Proto-Oncogene, AP-1 Transcription Factor Subunit | 0.754 | HT29_DSMO | TF | Involved in PARγ signaling and NAFLD development (61) |
Abbrevation: HAT, histone acetyltransferase.