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. 2023 Jan 10;4(2):134–149. doi: 10.1158/2643-3230.BCD-22-0154

Figure 2.

Figure 2. Landscape of recurrent genomic alterations in adult LH-ALL. A, Heat map of recurrent CNA and mutations in the 80 LH-ALL cases. Focal alterations refer to CNA not involving whole chromosome arms and mutations. Cases with several mutations are referred to as multihit. B, Lollipop plot depicting TP53 mutations detected in both LH-ALL and other Ph-negative B-ALL. C, Correlation between TP53 mutation VAF and blast percentage, as assessed by flow cytometry after ficoll or morphology on marrow smear, using Pearson correlation coefficient. D, Proportion of TP53 mutations in LH-ALL and other Ph-negative B-ALL with available data from the study cohort (n = 499).

Landscape of recurrent genomic alterations in adult LH-ALL. A, Heat map of recurrent CNA and mutations in the 80 LH-ALL cases. Focal alterations refer to CNA not involving whole chromosome arms and mutations. Cases with several mutations are referred to as multihit. B, Lollipop plot depicting TP53 mutations detected in both LH-ALL and other Ph-negative B-ALL. C, Correlation between TP53 mutation VAF and blast percentage, as assessed by flow cytometry after ficoll or morphology on marrow smear, using Pearson correlation coefficient. D, Proportion of TP53 mutations in LH-ALL and other Ph-negative B-ALL with available data from the study cohort (n = 499). Het, heterozygous; Hom: homozygous; indel: insertion/deletion.