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Nitrogen mustards. (a) Cross-linking mechanism. An aziridinium is formed that is attacked by the N7 nitrogen of guanine. Two consecutive reactions result in intra- or intermolecular cross-links. (b) Depurination mechanism. N7-alkylated guanine is electron poor, promoting cleavage of the N-glycosidic bond. (c) Molecular structure of nitrogen mustard derivatives.
