Table 5.
Association between CXCL8 rs4073 and TRL7 rs179008 allele frequencies with microcephaly severity.
| Gene/SNP | Severity of microcephaly | Allele comparisons | OR | 95% CI | p | |
|---|---|---|---|---|---|---|
| CSM (%) n = 42 |
CM (%) n = 18 |
|||||
| TREM1 rs2234246 | ||||||
| C | 39 (46.4) | 15 (41.7) | C vs. T | 1.21 | 0.54–2.59 | 0.691 |
| T | 45 (53.6) | 21 (58.3) | ||||
| CXCL10 rs4508917 | ||||||
| A | 58 (69.0) | 25 (69.4) | A vs. G | 0.98 | 0.43–2.18 | > 0.999 |
| G | 26 (31.0) | 11 (30.6) | ||||
| IL4 rs2243250 | ||||||
| C | 56 (66.7) | 29 (80.6) | C vs. T | 0.48 | 0.19–1.20 | 0.187 |
| T | 28 (33.3) | 7 (19.4) | ||||
| CXCL8 rs4073 | ||||||
| T | 40 (47.6) | 10 (27.8) | T vs. A | 2.36 | 1.00–5.51 | 0.046 |
| A | 44 (52.4) | 26 (72.2) | ||||
| TLR3 rs3775290 | ||||||
| C | 59 (70.2) | 26 (72.2) | C vs. T | 0.90 | 0.37–2.07 | > 0.999 |
| T | 25 (29.8) | 10 (27.8) | ||||
| TLR7 rs179008 | ||||||
| T | 21 (25.0) | 3 (8.3) | T vs. A | 3.66 | 1.06–12.2 | 0.046 |
| A | 63 (75.0) | 33 (91.7) | ||||
| IFNGR1 rs2234711 | ||||||
| A | 43 (51.2) | 18 (50.0) | A vs. G | 1.04 | 0.46–2.35 | > 0.999 |
| G | 41 (48.8) | 18 (50.0) | ||||
| CXCR1 rs2854386 | ||||||
| C | 74 (88.1) | 33 (91.7) | C vs. G | 0.67 | 0.18–2.60 | 0.752 |
| G | 10 (11.9) | 3 (8.3) | ||||
| IL10 rs1800871 | ||||||
| A | 34 (40.5) | 17 (47.2) | A vs. G | 0.76 | 0.33–1.73 | 0.548 |
| G | 50 (59.55) | 19 (52.8) | ||||
| IL10 rs1800872 | ||||||
| T | 34 (40.5) | 17 (47.2) | T vs. C | 0.76 | 0.33–1.73 | 0.548 |
| C | 50 (59.5) | 19 (52.8) | ||||
| IL10 rs1800896 | ||||||
| T | 38 (45.2) | 17 (47.2) | T vs. C | 0.92 | 0.41–2.09 | 0.844 |
| C | 46 (54.8) | 19 (52.8) | ||||
| CCR5 rs1800023 | ||||||
| A | 64 (76.2) | 27 (75.0) | A vs. G | 1.06 | 0.45–2.62 | > 0.999 |
| G | 20 (23.8) | 9 (25.0) | ||||
| CCR2 rs1799864 | ||||||
| A | 13 (15.5) | 8 (22.2) | A vs. G | 0.64 | 0.24–1.74 | 0.433 |
| G | 71 (84.5) | 28 (77.8) | ||||
| CCR5 rs1799987 | ||||||
| A | 40 (47.6) | 22 (61.1) | A vs. G | 0.57 | 0.26–1.28 | 0.231 |
| G | 44 (52.4) | 14 (38.9) | ||||
| CCR5 rs1800024 | ||||||
| C | 70 (83.3) | 28 (77.8) | C vs. T | 1.42 | 0.53–3.66 | 0.454 |
| T | 14 (16.7) | 8 (22.2) | ||||
| CCR5 rs1799988 | ||||||
| C | 41 (48.8) | 22 (61.1) | C vs. T | 0.60 | 0.27–1.35 | 0.237 |
| T | 43 (51.2) | 14 (38.9) | ||||
(%) number of subjects with the specified allele.
CSM, children with severe microcephaly due congenital Zika syndrome; CM, children with microcephaly due congenital Zika syndrome; p, Fisher's exact test.
Bold indicates statistically significant.