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. 2023 Mar 1;41(3):388–403. doi: 10.1007/s00774-023-01403-4

Fig. 1.

Fig. 1

Images of bone disease in patients with MM. A Myeloma tumor cells accumulate in the bone marrow. B Multiple compression fractures in lumbar vertebrae. C Multiple radiolucent lesions without ossification, known as “punched-out lesions” in a skull X-p, implying enhanced bone resorption along with impaired calcification. D Bone fractures in long bone occur in an advanced case