Figure EV4. In the absence of caspase‐1, ‐3 and  ‐7, cell death and IL‐1β release upon IAP inhibition do not depend on caspase‐6.

• A, B
  iBMDMs of the indicated genotypes were seeded at a density of 3 × 105 cells per well and primed with 100 ng/ml of LPS for 3 h before treatment with Cp. A (2 μM) for 24 h. Total cell lysates and supernatants were analysed by western blot (A) or cell viability determined by propidium iodide (PI) uptake and flow cytometry (B). Data representative of three independent experiments (A), or three independent experiments (symbols) are shown (B). Error bars represent the mean ± SD.

Source data are available online for this figure.