Table 3.
Association of VLOSLP with incident dementia: sensitivity analyses to take into account differences in detection by VLOSLP status due to previous contact with health services
| Fully adjusted Cox proportional hazards regression | ||||
|---|---|---|---|---|
| Variable | HR (95%CI) | 6-month washout HR (95%CI) N excluded: 8756 (5%) | 1-year washout HR (95%CI) N excluded: 11 451 (7%) | 2-year washout HR (95%CI) N excluded: 15 356 (9%) |
| N included (%) | 169 499 (100) | 160 743 (95) | 158 048 (93) | 154 143 (91) |
| VLOSLP (ref: comparison group, no diagnosis near date of entry) | 4.90 (4.69–5.13) | 3.63 (3.45–3.82) | 3.23 (3.06–3.41) | 2.61 (2.46–2.77) |
| VLOSLP (ref: comparison group, any diagnosis near date of entry)a | 2.89 (2.75–3.04) | 2.09 (1.98–2.21) | 1.84 (1.73–1.95) | 1.47 (1.38–1.56) |
| Fully adjusted Fine and Gray competing risks regression | ||||
| Variable | SHR (95% CI) | 6-month washout SHR (95%CI) N excluded: 8756 (5%) | 1-year washout SHR (95%CI) N excluded: 11 451 (7%) | 2-year washout SHR (95%CI) N excluded: 15 356 (9%) |
| N included (%) | 169 499 (100) | 160 743 (95) | 158 048 (93) | 154 143 (91) |
| VLOSLP (ref: comparison group, no diagnosis near date of entry) | 3.08 (2.94–3.22) | 2.21 (2.09–2.32) | 1.94 (1.84–2.05) | 1.54 (1.46–1.64) |
| VLOSLP (ref: comparison group, any diagnosis near date of entry)a | 2.52 (2.39–2.66) | 1.79 (1.69–1.90) | 1.56 (1.47–1.66) | 1.24 (1.16–1.32) |
Abbreviations: HR, hazard ratio; SHR, subdistribution hazard ratio; VLOSLP, very late-onset schizophrenia-like psychosis.
All analyses are adjusted for: VLOSLP group, sex, education level, family liability for non-affective psychotic disorder, disposable income at age 60, region of birth and matching variable.
a
Any hospital diagnosis on the year either side of entry into the study (except psychotic disorders or dementia).