Table 1.

Significant terms identified by GO enrichment analysis for down-regulated DEGs in ONFH samples (p<0.05).

Category	Term	Biological function	Count	P
BP	GO:0006955	Immune response	16	0.000000
	GO:0002250	Adaptive immune response	10	0.001707
	GO:0051607	Defense response to virus	9	0.000088
	GO:0002503	Peptide antigen assembly with MHC class II protein complex	8	0.000000
	GO:0002381	Immunoglobulin production involved in immunoglobulin mediated immune response	8	0.000000
	GO:0002504	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	8	0.000000
	GO:0019886	Antigen processing and presentation of exogenous peptide antigen via MHC class II	8	0.000000
	GO:0050870	Positive regulation of T cell activation	8	0.000000
	GO:0019882	Antigen processing and presentation	8	0.000000
	GO:0071222	Cellular response to lipopolysaccharide	8	0.000176
CC	GO:0005886	Plasma membrane	45	0.002669
	GO:0016021	Integral component of membrane	42	0.039437
	GO:0070062	Extracellular exosome	33	0.000001
	GO:0016020	Membrane	24	0.023415
	GO:0005887	integral component of plasma membrane	21	0.000495
	GO:0005765	Lysosomal membrane	11	0.000078
	GO:0000139	Golgi membrane	10	0.014823
	GO:0010008	Endosome membrane	9	0.000154
	GO:0009986	Cell surface	9	0.035184
	GO:0042613	MHC class II protein complex	8	0.000000
MF	GO:0005515	Protein binding	95	0.004893
	GO:0042803	Protein homodimerization activity	14	0.000688
	GO:0023026	MHC class II protein complex binding	8	0.000000
	GO:0042605	Peptide antigen binding	6	0.000004
	GO:0032395	MHC class II receptor activity	5	0.000001