. Author manuscript; available in PMC: 2023 Mar 1.

Published in final edited form as: J Bone Miner Res. 2021 Nov 24;37(2):285–302. doi: 10.1002/jbmr.4468

Table 1:

MicroCT parameters of constitutive GR-CKO and GR-WT bone at 3 months and 21 months of age

Parameter	Mean ± SE				p_genotype	p_age	p_{genotype × age interaction}

Ct. T.Ar (mm²)	1.687 ± 0.060^b	1.635 ± 0.062^b	1.986 ± 0.017^a	1.661 ± 0.034^b	0.0008	0.003	0.010
Ct. B.Ar (mm²)	0.658 ± 0.019^b	0.628 ± 0.026^b	0.783 ± 0.019^a	0.627 ± 0.019^b	0.0002	0.008	0.007
Ct. M.Ar (mm²)	1.029 ± 0.044	1.007 ± 0.038	1.203 ± 0.013	1.034 ± 0.042	0.019	0.014	0.065
Ct. BV/TV	0.391 ± 0.006	0.384 ± 0.006	0.394 ± 0.008	0.379 ± 0.015	0.245	0.902	0.652
Ct. lmax (mm⁴)	0.199 ± 0.013^ab	0.180 ± 0.015^b	0.240 ± 0.007^a	0.164 ± 0.006^b	0.0002	0.268	0.015
Ct. lmin(mm⁴)	0.101 ± 0.007^b	0.097 ± 0.008^b	0.160 ± 0.007^a	0.108 ± 0.003^b	0.0003	<0.0001	0.002
Ct.Th (mm)	0.145 ± 0.003	0.140 ± 0.004	0.161 ± 0.004	0.141 ± 0.006	0.006	0.036	0.077
Ct. TBMD (mg/cm³)	1.146 ± 0.012	1.106 ± 0.010	1.232 ± 0.008	1.200 ± 0.009	0.002	<0.0001	0.677
Tb.BV/TV	6.218 ± 0.595	4.342 ± 0.950	1.829 ± 1.477	0.078 ± 0.058	0.050	<0.0001	0.944
Tb.Th (mm)	0.046 ± 0.002	0.045 ± 0.001	0.042 ± 0.006	0.030 ± 0.005	0.078	0.019	0.126
Tb.N (1/mm)	1.373 ± 0.145	0.956 ± 0.204	0.438 ± 0.356	0.019 ± 0.012	0.052	0.0001	0.997
Tb.Sp (mm)	0.268 ± 0.018	0.328 ± 0.023	0.436 ± 0.019	0.461 ± 0.001	0.022	<0.0001	0.325

	3 mo GR-WT n=7	3 mo GR-CKO n=7	21 mo GR-WT n=6	21 mo GR-CKO n=7

Parameter means and standard errors (SE) are presented. P-values for variables and interactions assessed by two-factor analysis of variance (ANOVA) are shown. For properties where a significant interaction was detected between genotype and age, group means with different superscript letters are significantly (p<0.05) different from one another, as indicated by Tukey-Kramer HSD post-hoc testing.