Table 2.

Yields of Hoffmann analytes in regular- and menthol-flavored DT3.0a aerosols, 1R6F cigarette smoke, and air blanks.

Analytes	Unit	DT3.0a (Regular)				DT3.0a (Menthol)				Air Blank							1R6F				Air Blank
		Mean	±	95CI		Mean	±	95CI		Mean	±	95CI		LOD	LOQ		Mean	±	95CI		Mean	±	95CI		LOD	LOQ
Aromatic amines
1-aminonaphthalene	ng	< 0.027				0.115	±	0.011		<0.008				0.008	0.027		21.9	±	0.8		0.358	±	0.574		0.027	0.091
2-aminonaphthalene	ng	< 0.012				< 0.012				<0.004				0.004	0.012		15.4	±	1.3		0.384	±	0.606		0.012	0.040
3-aminobiphenyl	ng	< 0.004				0.006	±	0.003		<0.001				0.001	0.004		3.67	±	0.27		0.074	±	0.127		0.004	0.013
4-aminobiphenyl	ng	0.008	±	0.001		0.017	±	0.003		<0.001				0.001	0.005		2.54	±	0.19		0.052	±	0.082		0.005	0.016
Carbonyls
Formaldehyde	µg	4.67	±	0.42		3.42	±	0.29		2.04	±	0.24		0.361	1.20		85.6	±	5.1		2.6	±	0.2		0.361	1.20
Acetaldehyde	µg	93.7	±	4.3		98.8	±	5.1		<3.24				0.973	3.24		1406	±	75		6.07	±	1.89		0.973	3.24
Acetone	µg	10.3	±	0.4		12.1	±	0.3		<2.82				0.846	2.82		571	±	31		4.42	±	0.92		0.846	2.82
Acrolein	µg	2.82	±	0.22		< 2.38				<0.713				0.713	2.38		137	±	7		< 0.713				0.713	2.38
Propionaldehyde	µg	4.51	±	0.37		4.66	±	0.48		<1.00				1.00	3.34		98.9	±	5.2		< 1.00				1.00	3.34
Crotonaldehyde	µg	< 0.988				< 0.988				<0.988				0.988	3.29		44.2	±	4.3		< 0.988				0.988	3.29
Methyl Ethyl Ketone	µg	< 3.66				< 3.66				<1.10				1.10	3.66		145	±	11		< 3.66				1.10	3.66
Butyraldehyde	µg	< 0.812				< 0.812				<0.812				0.812	2.71		70.2	±	3.9		< 0.812				0.812	2.71
Phenolics
Hydroquinone	µg	3.97	±	0.10		3.82	±	0.08		<0.062				0.062	0.207		110	±	6		< 1.35				1.35	4.51
Resorcinol	µg	0.071	±	0.034		0.063	±	0.033		<0.016				0.016	0.055		1.75	±	0.18		< 0.395				0.395	1.32
Catechol	µg	10.2	±	0.5		11.4	±	0.5		<0.026				0.026	0.086		98.2	±	5.4		< 1.21				1.21	4.03
Phenol	µg	0.403	±	0.010		0.397	±	0.017		<0.026				0.026	0.086		14.3	±	1.8		< 1.43				1.43	4.78
p-cresol	µg	< 0.034				0.036	±	0.010		<0.010				0.010	0.034		8.21	±	0.77		< 0.207				0.207	0.691
m-cresol	µg	< 0.019				< 0.019				<0.006				0.006	0.019		3.23	±	0.29		< 0.451				0.451	1.50
o-cresol	µg	0.051	±	0.004		0.035	±	0.003		<0.008				0.008	0.026		4.02	±	0.41		< 0.184				0.184	0.614
PAH
Benzo(a)pyrene	ng	0.519	±	0.051		1.18	±	0.08		<0.106				0.106	0.354		13.4	±	0.5		< 0.177				0.177	0.590
Nitrogen oxides
NO	µg	2.65	±	0.35		2.84	±	0.24		<0.176				0.176	0.588		346	±	36		< 3.63				3.63	12.2
NOx	µg	3.35	±	0.32		3.54	±	0.17		<0.421				0.421	1.40		386	±	37		< 7.01				7.01	18.2
Cyanic compound
HCN	µg	< 1.75				< 1.75				<0.525				0.525	1.75		377	±	18		< 1.31				1.31	4.37
Amine
Ammonia	µg	4.94	±	0.38		14.9	±	1.6		1.02	±	0.29		0.184	0.613		28.6	±	2.8		< 1.46				1.46	4.88
Volatile organic compounds
1,3-butadiene	µg	< 0.095				< 0.095				<0.029				0.029	0.095		98.8	±	2.3		< 0.190				0.190	0.633
Isoprene	µg	< 0.135				< 0.135				<0.041				0.041	0.135		794	±	27		< 0.901				0.270	0.901
Acrylonitrile	µg	< 0.032				< 0.032				<0.032				0.032	0.107		19.5	±	0.9		< 0.213				0.213	0.711
Benzene	µg	0.128		0.008		0.107	±	0.018		<0.017				0.017	0.056		77.3	±	3.8		< 0.373				0.112	0.373
Toluene	µg	0.233		0.033		0.237	±	0.020		<0.061				0.061	0.204		124	±	3		< 1.36				0.408	1.36
PQS
Pyridine	µg	2.93	±	0.29		3.35	±	0.26		0.153	±	0.104		0.027	0.090		29.3	±	6.5		0.376	±	0.064		0.090	0.300
Quinoline	µg	< 0.011				< 0.011				<0.003				0.003	0.011		0.506	±	0.039		< 0.011				0.011	0.036
Styrene	µg	0.074	±	0.014		0.094	±	0.007		<0.012				0.012	0.039		13.7	±	4.2		< 0.129				0.039	0.129
Tobacco specific nitrosamines
NNN	ng	18.8	±	0.3		37.2	±	1.2		<0.098				0.098	0.328		185	±	13		< 0.164				0.164	0.547
NAT	ng	40.5	±	1.7		65.9	±	1.5		<0.195				0.195	0.650		269	±	83		< 0.325				0.325	1.08
NAB	ng	5.74	±	0.57		10.0	±	0.8		<0.054				0.054	0.179		24.2	±	4.4		< 0.089				0.089	0.298
NNK	ng	10.8	±	0.3		17.5	±	0.7		<0.151				0.151	0.502		211	±	24		< 0.251				0.251	0.836
Metals
Mercury	ng	1.62	±	0.11		1.44	±	0.13		<0.348				0.104	0.348		3.97	±	0.54		< 0.857				0.857	2.86
Cadmium	ng	< 0.150				< 0.150				<0.150				0.150	0.500		99.8	±	15.09		< 0.953				0.953	3.18
Lead	ng	< 1.00				< 1.00				<1.00				0.300	1.00		27.5	±	2.1		< 7.70				7.70	25.7
Chromium	ng	< 5.00				< 5.00				<5.00				1.50	5.00		< 11.9				< 11.9				11.9	39.6
Nickel	ng	< 10.0				< 10.0				<10.0				3.00	10.0		< 12.9				< 12.9				12.9	43.1
Arsenic	ng	< 1.50				< 1.50				<1.50				0.450	1.50		8.62	±	1.01		< 2.25				2.25	7.49
Selenium	ng	< 0.240				< 0.800				<0.240				0.240	0.800		< 4.42				< 4.42				4.42	14.7

The yields per tobacco stick for DT3.0a (11 puffs) and per cigarette for 1R6F (9–12 puffs) are presented. The yields of the air blank samples are also given. The mean ± 95CI values for five independent measurements are shown. The 95CI was not calculated if the mean for five replicate analyses was below LOD or if that was LOQ but above LOD. Abbreviations: 95CI 95% confidence interval, HCN hydrogen cyanide, LOD limit of detection, LOQ limit of quantification, NAB nitrosoanabasine, NAT nitrosoanatabine, NNK 4‐(methylnitrosoamino)‐1‐(3‐pyridyl)‐1‐butanone, NNN nitrosonornicotine, NO nitric oxide, NOx nitrogen oxides, PAH polycyclic aromatic hydrocarbon, PQS pyridine, quinoline, and styrene.