Table 1.
Clinical and Demographic Characteristics of Patients With Only OSA, Only CSC, or Both CSC and OSA, and CSC Treatment for Eyes of Patients with Only CSC or Both CSC and OSA.
| Total patients (N = 57) | Patients with CSC and OSA (n = 19) | Patients with only CSC (n = 20) | Patients with only OSA (n = 18) | P value | |
|---|---|---|---|---|---|
| Age, mean (SD), y | 58.5 (12.9) | 58.4 (13.0) | 59.6 (12.6) | 57.6 (13.8) | .895 |
| BMIa at diagnosis, mean (SD) | 28.9 (5.9) | 28.3 (5.3) | 24.1 (1.8) | 31.3 (6.5) | .006 |
| Sex, No. (%) | .537 | ||||
| Male | 48 (84.2) | 16 (84.2) | 18 (90.0) | 14 (77.8) | |
| Female | 9 (15.8) | 3 (15.8) | 2 (10.0) | 4 (22.2) | |
| Race/Ethnicity, No. (%) | <.0001 | ||||
| Non-Hispanic White | 26 (45.6) | 8 (42.1) | 20 (50.0) | 8 (44.4) | |
| Hispanic | 9 (15.8) | 5 (26.3) | 4 (20.0) | – | |
| Asian | 20 (35.1) | 4 (21.1) | 6 (30.0) | 10 (55.6) | |
| Other | 2 (3.5) | 2 (10.5) | – | – | |
| Smoking history, No. (%) | .499 | ||||
| Never smoker | 42 (73.7) | 14 (73.7) | 16 (80.0) | 12 (66.7) | |
| Prior smoker | 14 (25.9) | 5 (27.8) | 3 (15.8) | 6 (33.3) | |
| Current smoker | 1 (1.9) | – | 1 (5.3) | – | |
| AHI, median (IQR) | 24.7 (15.7-53.9) | 17.0 (14.1-24.5) | – | 31.2 (21.0-54.3) | .320 |
| OSA severity,b mean (SD) | .076 | ||||
| Mild | 11 (19.3) | 8 (42.1) | – | 3 (16.7) | |
| Moderate | 12 (21.1) | 7 (36.8) | – | 5 (27.8) | |
| Severe | 14 (24.6) | 4 (21.1) | – | 10 (55.6) | |
| Nocturnal SpO2 nadir,c median (IQR) | 85.0 (78.0-89.0) | 86.0 (80.3-89.3) | – | 80.0 (73.5-89.0) | .143 |
| ODI,d median (IQR) | 9.8 (6.5-50.4) | 7.9 (3.9-15.7) | – | 15.0 (7.0-63.0) | .236 |
| Total eyes with CSC and OSA or only CSC (n = 43) | Eyes with CSC and OSA (n = 22) | Eyes with only CSC (n = 21) | |||
| CSC treatment | .875 | ||||
| Intravitreal anti-VEGF injection | 3 (7.0) | 1 (4.5) | 2 (9.5) | – | |
| Photodynamic therapy | 10 (23.3) | 6 (27.3) | 4 (16.7) | – | |
| Laser photocoagulation | 1 (2.3) | – | 1 (4.8) | – | |
| Observation | 29 (67.4) | 15 (68.2) | 14 (66.7) | – |
Abbreviations: AHI, Apnea-Hypopnea Index; BMI, body mass index; CSC, central serous chorioretinopathy; IQR, interquartile range; ODI, Oxygen Desaturation Index; OSA, obstructive sleep apnea; SpO2, oxygen saturation; VEGF, vascular endothelial growth factor.
a Calculated as weight in kilograms divided by height in meters squared.
b Defined by American Academy of Sleep Medicine criteria: mild (5 ≤ AHI < 15), moderate (15 ≤ AHI < 30), and severe (AHI ≥ 30).
c Missing minimum nocturnal SpO2 nadir for 1 patient.
d Missing ODI for 10 patients.