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Structural representations of the two equilibrated dimeric structures which prelude to Pore I (A) and Pore II (B). The dimer in panel A is characterized by a face-to-face interaction between the ECL1 domains of two opposite Cldn5 protomers. The dimer in panel B is formed by a back-to-back interaction and stabilized by a leucine zipper pairs in the TM2–TM3 helices of the single Cldn5 protomers.
