Table 2.
Odds ratio (OR) and 95% confidence interval (CI) for intermediate/high Alzheimer’s disease neuropathological change (ADNC) by supplemental vitamin intake about 30 years earlier
| ADNC |
||||
|---|---|---|---|---|
| None/low (n=75) | Intermediate/high (n=189) | Unadjusted OR (95% CI) | Adjusted* OR (95% CI) | |
| Number (%) | ||||
|
|
||||
| Currently taking vitamin supplements | ||||
| No | 18 (24%) | 64 (34%) | 1.00 (reference) | 1.00 (reference) |
| Yes | 57 (76%) | 125 (66%) | 0.61 (0.33–1.14) | 0.60 (0.32–1.11) |
| Years regularly taken vitamin supplements | ||||
| <10 | 29 (40%) | 92 (51%) | 1.00 (reference) | 1.00 (reference) |
| 10–19 | 17 (23%) | 37 (20%) | 0.69 (0.34–1.40) | 0.71 (0.34–1.48) |
| 20+ | 27 (37%) | 52 (29%) | 0.61 (0.32–1.13) | 0.67 (0.35–1.28) |
| Supplementary vitamin A | ||||
| None | 31 (41%) | 106 (56%) | 1.00 (reference) | 1.00 (reference) |
| Low | 19 (25%) | 38 (20%) | 0.59 (0.30–1.16) | 0.64 (0.32–1.28) |
| High | 25 (33%) | 45 (24%) | 0.53 (0.28–0.99) | 0.53 (0.27–1.01) |
| Yes | 0.55 (0.32–0.95) | 0.58 (0.33–1.00) | ||
| Supplementary vitamin C | ||||
| None | 19 (25%) | 75 (40%) | 1.00 (reference) | 1.00 (reference) |
| Low | 37 (49%) | 63 (33%) | 0.43 (0.23–0.82) | 0.41 (0.21–0.79) |
| High | 19 (25%) | 51 (27%) | 0.68 (0.33–1.41) | 0.71 (0.34–1.51) |
| Yes | 0.52 (0.28–0.94) | 0.51 (0.27–0.93) | ||
| Supplementary vitamin E | ||||
| None | 24 (32%) | 91(48%) | 1.00 (reference) | 1.00 (reference) |
| Low | 25 (33%) | 47 (25%) | 0.50 (0.26–0.96) | 0.51 (0.26–1.00) |
| High | 26 (35%) | 51 (27%) | 0.52 (0.27–0.99) | 0.53 (0.27–1.04) |
| Yes | 0.51 (0.29–0.89) | 0.52 (0.29–0.92) | ||
*
Adjusted for age at LWCS entry, age at death, sex, and education (college graduate no/yes).