Table 2.
The association between various systematic information indicators and three arrhythmia subtypes
| Variables | Atrial fibrillation/flutter | Ventricular arrhythmia | Bradyarrhythmia | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | |
| C-reactive protein (mg/L) | |||||||||
| <0.5 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| (0.5, 1.0) | 1.10 (1.05~1.16) | 0.99 (0.94~1.04) | 1.00 (0.95~1.05) | 1.10 (0.97~1.25) | 1.03 (0.90~1.17) | 1.06 (0.93~1.20) | 1.11 (1.04~1.20) | 1.02 (0.94~1.09) | 1.04 (0.97~1.13) |
| (1.0, 2.0) | 1.21 (1.16~1.27) | 0.98 (0.94~1.03) | 1.00 (0.95~1.05) | 1.32 (1.17~1.48) | 1.15 (1.01~1.30) | 1.20 (1.06~1.36) | 1.16 ((1.08~1.24) | 0.98 (0.91~1.06) | 1.03 (0.96~1.11) |
| (2.0, 3.0) | 1.37 (1.30~1.44) | 1.02 (0.96~1.08) | 1.04 (0.98~1.10) | 1.32 (1.16~1.51) | 1.06 (0.92~1.23) | 1.13 (0.98~1.30) | 1.26 (1.17~1.37) | 1.01 (0.93~1.10) | 1.07 (0.98~1.16) |
| (3.0, 4.0) | 1.47 (1.39~1.56) | 1.04 (0.97~1.10) | 1.06 (0.99~1.13) | 1.54 (1.32~1.79) | 1.20 (1.02~1.42) | 1.28 (1.09~1.51) | 1.42 (1.30~1.55) | 1.08 (0.98~1.19) | 1.15 (1.05~1.27) |
| (4.0, 10.0) | 1.72 (1.63~1.81) | 1.12 (1.06~1.19) | 1.14 (1.07~1.20) | 1.92 (1.69~2.18) | 1.37 (1.19~1.58) | 1.45 (1.26~1.67) | 1.54 (1.42~1.66) | 1.11 (1.02~1.21) | 1.18 (1.08~1.29) |
| >=10.0 | 2.10 (1.97~2.23) | 1.33 (1.24~1.43) | 1.33 (1.24~1.43) | 2.55 (2.18~2.98) | 1.81 (1.53~2.16) | 1.87 (1.57~2.22) | 1.68 (1.52~1.86) | 1.23 (1.10~1.37) | 1.30 (1.16~1.45) |
| Neutrophil count (10^9 cells/L) | |||||||||
| <2.0 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| (2.0, 3.0) | 0.97 (0.86~1.09) | 1.00 (0.88~1.13) | 1.02 (0.90~1.16) | 1.06 (0.77~1.45) | 1.07 (0.77~1.49) | 1.10 (0.79~1.53) | 0.85 (0.72~1.00) | 0.84 (0.70~1.00) | 0.85 (0.71~1.01) |
| (3.0, 4.0) | 1.02 (0.91~1.14) | 0.98 (0.87~1.11) | 0.99 (0.88~1.11) | 1.21 (0.90~1.64) | 1.13 (0.82~1.56) | 1.14 (0.83~1.56) | 0.93 (0.80~1.10) | 0.89 (0.75~1.05) | 0.88 (0.74~1.04) |
| (4.0, 5.0) | 1.14 (1.02~1.28) | 1.05 (0.93~1.18) | 1.03 (0.91~1.16) | 1.34 (0.99~1.81) | 1.19 (0.87~1.64) | 1.17 (0.85~1.60) | 1.02 (0.87~1.20) | 0.93 (0.79~1.10) | 0.90 (0.76~1.06) |
| (5.0, 6.0) | 1.29 (1.15~1.45) | 1.12 (0.99~1.26) | 1.08 (0.95~1.22) | 1.82 (1.34~2.47) | 1.52 (1.10~2.09) | 1.43 (1.04~1.97) | 1.15 (0.98~1.36) | 1.01 (0.85~1.20) | 0.94 (0.79~1.11) |
| (6.0, 7.5) | 1.53 (1.36~1.72) | 1.25 (1.10~1.41) | 1.17 (1.03~1.33) | 2.18 (1.59~2.97) | 1.73 (1.24~2.40) | 1.57 (1.13~2.18) | 1.28 (1.08~1.51) | 1.07 (0.90~1.28) | 0.98 (0.82~1.17) |
| >=7.5 | 1.88 (1.65~2.13) | 1.49 (1.30~1.71) | 1.36 (1.19~1.55) | 3.35 (2.42~4.64) | 2.43 (1.72~3.43) | 2.13 (1.51~3.01) | 1.42 (1.17~1.71) | 1.19 (0.98~1.45) | 1.05 (0.86~1.28) |
| Monocyte count (10^9 cells/L) | |||||||||
| <0.3 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| (0.3, 0.4) | 0.98 (0.92~1.04) | 1.00 (0.94~1.06) | 1.00 (0.94~1.06) | 0.91 (0.78~1.07) | 0.93 (0.79~1.09) | 0.93 (0.79~1.1) | 0.95 (0.86~1.04) | 0.97 (0.88~1.07) | 0.97 (0.88~1.07) |
| (0.4, 0.5) | 1.03 (0.98~1.09) | 1.01 (0.95~1.07) | 1.00 (0.94~1.06) | 1.01 (0.87~1.17) | 1.03 (0.88~1.20) | 1.02 (0.87~1.19) | 0.98 (0.90~1.07) | 0.98 (0.90~1.08) | 0.97 (0.89~1.06) |
| (0.5, 0.6) | 1.11 (1.05~1.18) | 1.04 (0.98~1.10) | 1.02 (0.96~1.08) | 1.17 (1.01~1.36) | 1.11 (0.95~1.30) | 1.09 (0.93~1.27) | 1.06 (0.97~1.16) | 1.01 (0.92~1.11) | 0.99 (0.90~1.08) |
| (0.6, 0.7) | 1.24 (1.17~1.32) | 1.11 (1.04~1.19) | 1.08 (1.01~1.15) | 1.24 (1.06~1.45) | 1.11 (0.94~1.31) | 1.06 (0.90~1.25) | 1.15 (1.05~1.26) | 1.07 (0.97~1.18) | 1.02 (0.93~1.13) |
| (0.7, 0.8) | 1.40 (1.31~1.50) | 1.20 (1.11~1.28) | 1.13 (1.05~1.22) | 1.57 (1.33~1.86) | 1.38 (1.15~1.65) | 1.27 (1.06~1.53) | 1.34 (1.21~1.48) | 1.19 (1.07~1.32) | 1.11 (1.00~1.24) |
| >=0.8 | 1.58 (1.47~1.69) | 1.28 (1.19~1.38) | 1.18 (1.10~1.27) | 2.14 (1.81~2.52) | 1.79 (1.50~2.13) | 1.58 (1.33~1.89) | 1.3 (1.17~1.45) | 1.14 (1.02~1.28) | 1.03 (0.92~1.15) |
| Lymphocyte count (10^9 cells/L) | |||||||||
| <0.8 | 1.55 (1.37~1.75) | 1.74 (1.53~1.98) | 1.56 (1.38~1.78) | 1.57 (1.17~2.12) | 1.59 (1.14~2.22) | 1.39 (0.99~1.95) | 1.34 (1.11~1.63) | 1.42 (1.15~1.74) | 1.33 (1.08~1.64) |
| (0.8, 1.5) | 1.01 (0.98~1.05) | 1.15 (1.10~1.19) | 1.13 (1.09~1.18) | 1.04 (0.94~1.14) | 1.18 (1.07~1.31) | 1.16 (1.05~1.29) | 0.97 (0.91~1.02) | 1.04 (0.98~1.11) | 1.04 (0.98~1.10) |
| (1.5, 2.0) | 0.99 (0.96~1.03) | 1.06 (1.02~1.1) | 1.05 (1.02~1.09) | 0.89 (0.82~0.98) | 0.97 (0.88~1.06) | 0.97 (0.88~1.06) | 0.99 (0.94~1.05) | 1.04 (0.98~1.09) | 1.04 (0.98~1.09) |
| (2.0, 2.5) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| (2.5, 3.0) | 1.04 (0.99~1.09) | 0.98 (0.93~1.03) | 0.97 (0.92~1.02) | 1.09 (0.97~1.23) | 1.01 (0.90~1.15) | 0.99 (0.88~1.12) | 1.02 (0.95~1.10) | 0.96 (0.89~1.03) | 0.94 (0.87~1.01) |
| (3.0, 4.0) | 1.17 (1.10~1.24) | 1.02 (0.95~1.08) | 0.99 (0.93~1.06) | 1.32 (1.14~1.53) | 1.13 (0.97~1.32) | 1.08 (0.92~1.26) | 1.32 (1.21~1.44) | 1.23 (1.12~1.35) | 1.18 (1.07~1.29) |
| >=4.0 | 1.35 (1.18~1.53) | 1.17 (1.02~1.35) | 1.10 (0.96~1.27) | 1.66 (1.23~2.25) | 1.39 (1.00~1.93) | 1.28 (0.92~1.77) | 1.32 (1.08~1.61) | 1.17 (0.94~1.46) | 1.11 (0.89~1.38) |
| Systemic immune-inflammation index (SII) | |||||||||
| <300 | 1.08 (1.02~1.13) | 1.07 (1.01~1.13) | 1.07 (1.01~1.13) | 1.15 (1.00~1.31) | 1.15 (1.00~1.32) | 1.14 (0.99~1.31) | 1.11 (1.03~1.20) | 1.10 (1.02~1.19) | 1.11 (1.02~1.20) |
| (300, 400) | 1.06 (1.01~1.10) | 1.05 (1.00~1.10) | 1.06 (1.01~1.11) | 1.13 (1.01~1.28) | 1.13 (1.00~1.27) | 1.13 (1.00~1.28) | 1.01 (0.94~1.08) | 1.00 (0.93~1.07) | 1.00 (0.93~1.08) |
| (400, 500) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| (500, 600) | 1.05 (1.01~1.10) | 1.04 (0.99~1.08) | 1.03 (0.98~1.08) | 1.16 (1.03~1.31) | 1.14 (1.01~1.29) | 1.14 (1.01~1.29) | 1.03 (0.96~1.10) | 1.02 (0.95~1.10) | 1.02 (0.95~1.09) |
| (600, 800) | 1.11 (1.06~1.16) | 1.09 (1.04~1.13) | 1.07 (1.02~1.11) | 1.20 (1.07~1.34) | 1.18 (1.05~1.32) | 1.16 (1.03~1.30) | 1.08 (1.01~1.15) | 1.06 (1,00~1.14) | 1.05 (0.98~1.12) |
| (800, 1500) | 1.22 (1.17~1.27) | 1.18 (1.13~1.23) | 1.13 (1.08~1.19) | 1.54 (1.38~1.72) | 1.46 (1.30~1.65) | 1.41 (1.25~1.58) | 1.15 (1.08~1.23) | 1.12 (1.04~1.20) | 1.08 (1.01~1.16) |
| >=1500 | 1.69 (1.56~1.83) | 1.62 (1.49~1.77) | 1.48 (1.36~1.62) | 2.88 (2.41~3.44) | 2.65 (2.19~3.21) | 2.39 (1.98~2.9) | 1.39 (1.22~1.58) | 1.37 (1.19~1.58) | 1.29 (1.12~1.49) |
| Neutrophil-to-lymphocyte ratio (NLR) | |||||||||
| <1.5 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| (1.5, 2.0) | 1.00 (0.96~1.04) | 1.00 (0.96~1.05) | 0.99 (0.95~1.04) | 1.04 (0.93~1.17) | 1.02 (0.91~1.15) | 1.01 (0.90~1.14) | 0.99 (0.93~1.06) | 0.99 (0.92~1.06) | 0.98 (0.91~1.05) |
| (2.0, 2.5) | 1.07 (1.02~1.12) | 1.06 (1.02~1.11) | 1.04 (1.00~1.09) | 1.14 (1.02~1.28) | 1.13 (1.00~1.27) | 1.10 (0.98~1.24) | 1.04 (0.97~1.11) | 1.03 (0.97~1.11) | 1.01 (0.94~1.08) |
| (2.5, 3.0) | 1.15 (1.10~1.21) | 1.13 (1.07~1.19) | 1.10 (1.04~1.15) | 1.18 (1.04~1.33) | 1.14 (1.00~1.30) | 1.10 (0.96~1.25) | 1.06 (0.99~1.14) | 1.05 (0.98~1.14) | 1.02 (0.94~1.10) |
| (3.0, 3.5) | 1.22 (1.16~1.29) | 1.21 (1.14~1.28) | 1.16 (1.10~1.22) | 1.33 (1.16~1.53) | 1.29 (1.12~1.49) | 1.22 (1.06~1.41) | 1.18 (1.09~1.28) | 1.17 (1.08~1.28) | 1.12 (1.03~1.21) |
| (3.5, 5.0) | 1.36 (1.29~1.44) | 1.36 (1.29~1.43) | 1.28 (1.21~1.35) | 1.69 (1.48~1.92) | 1.61 (1.41~1.85) | 1.49 (1.30~1.71) | 1.19 (1.10~1.29) | 1.17 (1.08~1.27) | 1.10 (1.01~1.20) |
| >=5.0 | 1.64 (1.53~1.77) | 1.62 (1.50~1.75) | 1.46 (1.35~1.58) | 2.33 (1.97~2.75) | 2.18 (1.82~2.61) | 1.91 (1.59~2.28) | 1.38 (1.23~1.55) | 1.36 (1.20~1.53) | 1.23 (1.09~1.39) |
| Platelet-to-lymphocyte ratio (PLR) | |||||||||
| <80 | 1.22 (1.16~1.28) | 1.11 (1.05~1.17) | 1.08 (1.02~1.14) | 1.40 (1.23~1.59) | 1.22 (1.07~1.40) | 1.15 (1.00~1.32) | 1.23 (1.14~1.33) | 1.14 (1.05~1.24) | 1.10 (1.01~1.19) |
| (80, 100) | 1.09 (1.05~1.14) | 1.05 (1.00~1.10) | 1.04 (0.99~1.09) | 1.22 (1.08~1.36) | 1.12 (1.00~1.27) | 1.10 (0.97~1.24) | 1.05 (0.98~1.13) | 1.02 (0.95~1.09) | 1.01 (0.94~1.08) |
| (100, 120) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| (120, 150) | 0.99 (0.95~1.03) | 1.02 (0.98~1.06) | 1.02 (0.97~1.06) | 1.01 (0.91~1.12) | 1.04 (0.93~1.16) | 1.04 (0.94~1.16) | 0.97 (0.91~1.03) | 0.98 (0.92~1.04) | 0.98 (0.92~1.05) |
| (150, 200) | 0.98 (0.94~1.02) | 1.04 (0.99~1.08) | 1.04 (0.99~1.08) | 0.94 (0.85~1.05) | 1.00 (0.9~1.12) | 1.01 (0.90~1.13) | 0.93 (0.87~0.99) | 0.97 (0.91~1.03) | 0.98 (0.92~1.04) |
| (200, 250) | 0.98 (0.92~1.03) | 1.06 (0.99~1.12) | 1.04 (0.98~1.11) | 1.17 (1.02~1.35) | 1.24 (1.07~1.44) | 1.24 (1.07~1.44) | 0.96 (0.88~1.05) | 1.01 (0.92~1.10) | 1.01 (0.93~1.11) |
| >=250 | 1.12 (1.05~1.21) | 1.26 (1.17~1.35) | 1.19 (1.10~1.28) | 1.50 (1.27~1.77) | 1.56 (1.31~1.86) | 1.47 (1.24~1.76) | 1.06 (0.95~1.18) | 1.14 (1.01~1.27) | 1.11 (0.99~1.24) |
| Lymphocyte-to-monocyte ratio (LMR) | |||||||||
| <2.5 | 1.47 (1.39~1.56) | 1.49 (1.40~1.58) | 1.39 (1.30~1.47) | 1.79 (1.54~2.07) | 1.82 (1.55~2.13) | 1.66 (1.42~1.95) | 1.25 (1.15~1.37) | 1.23 (1.12~1.35) | 1.16 (1.06~1.27) |
| (2.5, 3.0) | 1.23 (1.16~1.31) | 1.24 (1.17~1.32) | 1.19 (1.12~1.27) | 1.54 (1.32~1.79) | 1.63 (1.39~1.91) | 1.55 (1.33~1.82) | 1.06 (0.97~1.15) | 1.04 (0.94~1.14) | 1.00 (0.91~1.10) |
| (3.0, 4.0) | 1.14 (1.08~1.20) | 1.15 (1.09~1.21) | 1.12 (1.06~1.19) | 1.19 (1.04~1.37) | 1.27 (1.10~1.47) | 1.24 (1.07~1.43) | 1.05 (0.98~1.14) | 1.05 (0.97~1.14) | 1.03 (0.95~1.11) |
| (4.0, 5.0) | 1.07 (1.01~1.12) | 1.08 (1.02~1.14) | 1.07 (1.01~1.13) | 1.15 (1.00~1.33) | 1.2 (1.03~1.39) | 1.19 (1.03~1.38) | 0.99 (0.91~1.07) | 0.98 (0.90~1.06) | 0.97 (0.89~1.06) |
| (5.0, 6.0) | 1.04 (0.98~1.10) | 1.05 (0.99~1.11) | 1.04 (0.98~1.11) | 1.05 (0.90~1.22) | 1.07 (0.91~1.26) | 1.07 (0.91~1.27) | 0.98 (0.89~1.07) | 0.96 (0.87~1.05) | 0.96 (0.87~1.05) |
| (6.0, 8.0) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| >=8.0 | 1.05 (0.97~1.14) | 1.02 (0.94~1.11) | 1.02 (0.93~1.11) | 1.32 (1.08~1.61) | 1.28 (1.03~1.58) | 1.28 (1.03~1.58) | 1.08 (0.96~1.22) | 1.07 (0.94~1.21) | 1.07 (0.94~1.21) |
Ref Reference
Model 1: Adjusted age, sex, and race
Model 2: Adjusted Model 1+townsend deprivation index, education, BMI, smoking status, frequency of alcohol drinking, and physical activity
Model 3: Adjusted Model 2+hypertension, heart attack, angina, stroke, diabetes, hyperlipidemia, diseases of blood and blood-forming organs, chronic diseases involving the immune mechanism, and malignant neoplasms