Table 1.
Signs, symptoms, and impact of RSV identified in the literature
| RSV signs and symptoms and patient experiences | Literature source | RSV-iiiQ | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | Total a | ||
| Respiratory symptoms | |||||||||||||||||
| Coryza (catarrhal inflammation of the mucous membrane in the nose) | x | 1 | |||||||||||||||
| Cough | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 14 | x (and cough with phlegm) | |
| Crackles | x | 1 | |||||||||||||||
| Croup-like cough | x | 1 | |||||||||||||||
| Dyspnea (difficulty breathing, shortness of breath) | x | x | x | x | x | x | x | x | x | x | x | x | x | 13 | x | ||
| Nasal congestion | x | x | x | x | x | x | x | x | x | x | 10 | x | |||||
| Orthopnea | x | 1 | |||||||||||||||
| Rales | x | x | x | 3 | |||||||||||||
| Rhinitis | x | 1 | |||||||||||||||
| Rhinorrhea | x | x | x | x | x | 5 | |||||||||||
| Rhonchi | x | x | 2 | ||||||||||||||
| Sputum production | x | x | x | x | x | 5 | |||||||||||
| Wheezing | x | x | x | x | x | x | x | x | x | x | x | x | 12 | x | |||
| Infections | |||||||||||||||||
| Bacteremia | x | 1 | |||||||||||||||
| Bronchiolitis | x | 1 | |||||||||||||||
| Pain | |||||||||||||||||
| Chest pain | x | x | 2 | ||||||||||||||
| Chills | x | 1 | |||||||||||||||
| Ear pain | x | x | x | 3 | |||||||||||||
| Headache | x | x | x | x | x | 5 | x | ||||||||||
| Muscle aches | x | 1 | x (body aches and pains) | ||||||||||||||
| Myalgias | x | x | x | x | 4 | x (body aches and pains) | |||||||||||
| Sinus pain | x | x | 2 | ||||||||||||||
| Nausea/abdominal pain | x | 1 | |||||||||||||||
| Sore throat/pharyngitis | x | x | x | x | x | x | x | x | x | x | x | x | x | 13 | x | ||
| Systemic symptoms | |||||||||||||||||
| General systemic symptoms not described (group of symptoms that can affect many different systems of the body) | x | x | 2 | ||||||||||||||
| Fatigue | x | 1 | x | ||||||||||||||
| Lethargy/malaise | x | x | 2 | ||||||||||||||
| Weakness | x | 1 | |||||||||||||||
| Fever-related symptoms | |||||||||||||||||
| Febrile seizures | x | 1 | |||||||||||||||
| Fever or feverishness | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 14 | x | |
| Rigors (a sudden feeling of cold with shivering accompanied by a rise in temperature, often with copious sweating, especially at onset or height of a fever) | x | 1 | |||||||||||||||
| Sweating | x | 1 | |||||||||||||||
| Other, including symptoms and impacts | |||||||||||||||||
| Hoarseness | x | x | x | x | 4 | ||||||||||||
| Vomiting | x | 1 | |||||||||||||||
| Work/training absence | x | x | 2 | ||||||||||||||
| Diarrhea | x | 1 | |||||||||||||||
| Interrupted sleep b | 0 | x | |||||||||||||||
| Loss of appetite b | 0 | x | |||||||||||||||
| Hospitalization due to RSV | xc | x | xc | x | x | xc | x | 7 | |||||||||
| ICU | x | x | 2 | ||||||||||||||
| Ward confinement | x | 1 | |||||||||||||||
| Inability to complete ADLs | x | 1 | x | ||||||||||||||
| Inability to get out of bed | x | 1 | x | ||||||||||||||
| Prepare meals/Get your own food b | 0 | x | |||||||||||||||
| Perform your usual activities b | 0 | x | |||||||||||||||
| Leave the home b | 0 | x | |||||||||||||||
| Concentrate on tasks b | 0 | x | |||||||||||||||
| Take care of yourself b | 0 | x | |||||||||||||||
| Walk up a flight of stairs b | 0 | x | |||||||||||||||
| Dress yourself b | 0 | x | |||||||||||||||
| Irritable b | 0 | x | |||||||||||||||
| Helpless b | 0 | x | |||||||||||||||
| Frustrated b | 0 | x | |||||||||||||||
| Worried b | 0 | x | |||||||||||||||
ADL Activity of daily living, ICU Intensive care unit, RSV Respiratory syncytial virus, RSV-iiiQ RSV Infection, Intensity and Impact Questionnaire
aTotal number of identified resources mentioning the specific sign or symptom
bAdditional ADLs and emotional impacts identified in the influenza literature[10, 25, 26]
cStudy sample was defined as individuals who were hospitalized
Sources: 1, Walsh et al. [27]; 2, Dowell et al. [28]; 3, Falsey et al. [2]; 4, O'Shea et al. [29]; 5, Falsey and Walsh [4]; 6, Hall et al. [7]; 7, Branche and Falsey [1]; 8, Sundaram et al. [17]; 9, Volling et al. [3]; 10, Wald et al. [30]; 11, Li et al. [14]; 12, Uckay et al. [18]; 13, Loubet et al. [15]; 14, Saxena et al. [16]; 15, Falsey et al. [2]