Table 3.
Factors associated with liver-related mortality or LT in PBC.
| Factor | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Age ≥65 years | 1.181 | 1.003–1.390 | 0.046 | 1.268 | 1.026–1.566 | 0.028 |
| Male | 1.268 | 1.050–1.532 | <0.0001 | |||
| Symptomatic | 7.485 | 6.470–8.660 | <0.0001 | 3.735 | 3.084–4.524 | <0.0001 |
| ALP ≥1.67 xULN | 3.107 | 2.570–3.757 | <0.0001 | 1.927 | 1.577–2.355 | <0.0001 |
| Total bilirubin ≥1.0 mg/dl | 6.702 | 5.820–7.719 | <0.0001 | |||
| Albumin <3.9 g/dl | 4.192 | 3.668–4.790 | <0.0001 | |||
| ALBI score ≥-2.518 | 7.040 | 6.107–8.115 | <0.0001 | |||
| ALBI grade ≥2 | 5.928 | 5.123–6.860 | <0.0001 | 4.242 | 3.421–5.260 | <0.0001 |
The Cox proportional hazard model included age, sex, symptomatic status, ALP, and ALBI grade for calculations considering the multicollinearity of albumin, total bilirubin, and ALBI grade, whose condition number was 1.440.
ALBI, albumin-bilirubin; ALP, alkaline phosphatase; HR, hazard ratio; LT, liver transplantation; PBC, primary biliary cholangitis; ULN, upper limit of normal.