Title	The efficacy and safety of intravenous ketamine for chronic daily headaches: Trial protocol for a randomized controlled “KetHead” trial
Primary registry and trial identifying number	ClinicalTrials.gov NCT05306899
Other protocol identifier	21-5523
Date of registration in primary registry	April 1, 2022
Protocol version	Version 3.0 dated 16Aug2022
Funding	Canadian Pain Society and Pfizer Canada
Author details	Yasmine Hoydonckx MD MSc FIPP Mandeep Singh MBBS MD MSc FRCPC Jamal Kara MSc CCRP Anuj Bhatia MBBS MD PhD FCCPC Department of Anesthesia and Pain Medicine, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada Ian Gilron MD MSc Department of Anesthesiology and Perioperative Medicine, Queens University, Kingston, Canada James Khan MD MSc FRCPC Department of Anesthesia and Pain Medicine, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada Samer Narouze MD PhD Department of Anesthesia and Pain Medicine, Western Reserve Hospital, Cuyahoga Falls, Ohio, USA Albert Dahan MD PhD Department of Anesthesiology, Leiden University, Leiden, The Netherlands Kathryn Curtis PhD, C. Psych. Comprehensive Integrated Pain Program, University Health Network, Toronto, Canada Xingshan Cao PhD Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
Primary sponsor	Department of Anesthesia and Pain Management University Health Network 399 Bathurst Street, 2-McL Toronto, ON M5T 2S8 Tel: (416) 603-5800 ext. 6237 Fax: (416) 603-6494
Contact for public queries	Department of Anesthesia and Pain Management Toronto Western Hospital, University Health Network, 399 Bathurst Street Toronto
Contact for scientific queries	Principal Investigator: Yasmine Hoydonckx MD, MSc, FIPP Toronto Western Hospital, University Health Network 399 Bathurst Street, 2-McL Toronto, ON M5T 2S8 yasmine.hoydonckx@uhn.ca Tel: (416) 603-5800 ext. 6237 Fax: (416) 603-6494 Contact for scientific queries: Jamal Kara MSc, CCRP Trial Coordinator Department of Anesthesia and Pain Management Toronto Western Hospital, University Health Network 399 Bathurst Street, 2-McL Toronto, ON M5T 2S8 Jamal.kara@uhn.ca kawalpreet.singh@uhnresearch.ca Tel: (416) 603-5800 ext. 6237 Fax: (416) 603-6494
Role of sponsor	The sponsor or funders have no role in the trial design, collection, management, analysis, and interpretation of the data; writing of the report; and the decision to submit the report for publication.