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. 2023 Mar 1;22:41. doi: 10.1186/s12943-023-01747-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — BC069792 inhibits the proliferation and invasion of breast cancer cells in vivo. a In vivo imaging of nude mice showed that the volume of the subcutaneous tumor in the LV-BC069792 group was significantly smaller than that of the LV-NC group. One nude mouse in the LV-BC069792 group had no tumor. b The growth curve showed that the tumor growth rate of the LV-NC group was significantly higher than that of the LV-BC069792 group (P = 0.0081). c The removal of subcutaneous tumors showed that the tumor volume in the LV-BC069792 group was significantly smaller than that of the LV-NC group, and the tumor of a nude mouse in the LV-BC069792 group were suppressed. d The content of BC069792 in tumor tissue in LV-BC069792 group was significantly higher than that in LV-NC group (P = 0.0051). e The Ki-67 index of the LV-BC069792 group was about 25%, and the Ki-67 index of the LV-NC group was about 80% (IHC × 200). The Ki-67 index of the LV-BC069792 group was significantly lower than that of the LV-NC group (P = 0.0059). f In lung metastasis, the expression of BC069792 in LV-BC069792 group was significantly higher than that in LV-NC group (P = 0.0228). g The gross image of the lung metastases in nude mice showed that the tumor growth at the hilum and outside the lung of the nude mice in the LV-NC group was obvious. In LV-BC069792 group, there were no obvious tumors in the lungs of nude mice. HE staining results showed that the lung metastases in the LV-NC group were significantly increased and the volume was significantly increased. The scatter plot showed that the number of metastases in the overexpression BC069792 group was significantly reduced (P = 0.0267). h There was liver-diaphragm metastasis in the LV-NC group, but no cancer metastasis in the liver and diaphragm of the LV-BC069792 group. i The tumor cells in the LV-NC group invaded the skin adnexa, while the tumor cells in the LV-BC069792 group had a clear boundary with the surrounding adipose tissue and mammary tubules, and no obvious invasion was found. (P < 0.05, P < 0.01, P < 0.001,.P < 0.0001, ns represent P > 0.05)^*^**^***^****