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. 2023 Mar 1;22:41. doi: 10.1186/s12943-023-01747-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — KCNQ4 is a downstream target gene of BC069792. a RT-qPCR results showed that overexpression of BC069792 affected the expression of multiple genes in MDA-MB-231 cells, among which the increase of KCNQ4 was the most significant. b Western blot showed that the expression of KCNQ4 protein in the BC069792 overexpression group was significantly higher than that in the control group (MDA-MB-231: P = 0.0271, MDA-MB-468: P = 0.0088). c The mRNA expression of KCNQ4 in normal breast tissue was significantly higher than that in breast cancer tissue (P = 0.0145). d The protein expression of KCNQ4 in normal breast tissue was significantly higher than that in breast cancer tissue (P = 0.031). e and f In axillary tumors of mice, the expression of mRNAand protein of KCNQ4 in LV-BC069792 group was significantly higher than that in LV-NC group. g and h In lung metastasesof mice, the expression of mRNAand proteinof KCNQ4 in LV-BC069792 group was significantly higher than that in LV-NC group. i The content of KCNQ4 protein in LV-BC069792 tumor tissues of nude mice was significantly higher than that in LV-NC nude mice (P = 0.0051). j In human tumor tissue and nude mouse tumor tissue, BC069792 and KCNQ4 had a significant positive correlation. k BC069792 can promote the RNA stability of KCNQ4.(P < 0.05, P < 0.01, P < 0.001,.P < 0.0001, ns represent P > 0.05)^*^**^***^****