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. 2023 Mar 1;22:41. doi: 10.1186/s12943-023-01747-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The downstream effector molecule regulated by KCNQ4 is JAK2/p-AKT. a After overexpression of BC069792, the mRNA expression of KCNQ4 was positively correlated with BC069792 and negatively correlated with JAK2. b After overexpression of BC069792, the protein expression of KCNQ4 was positively correlated with BC069792 and negatively correlated with JAK2. c In MDA-MB-231 (P = 0.0047) cell lines, overexpression of BC069792 reduced the expression of p-AKT protein. d In the BC069792 overexpression MDA-MB-231 cells, the protein content of KCNQ4 was significantly higher than that of p-AKT (P = 0.032), while the content of KCNQ4 and p-AKT in the pcDNA3.1 group was not statistically significant (P = 0.194). e In MDA-MB-231 cells, KCNQ4 was negatively correlated with p-AKT(r = -0.943, P = 0.017). f The expression of p-AKT protein in tumor tissue of nude mice was significantly different between LV-BC06972 group and LV-NC group, and it was highly expressed in LV-NC group(P = 0.001