Table 3.
Additional significant CpGs identified in meta-analysis of blood lipids EWAS among survivors of European and African ancestry (P < 9 × 10−8)
| EWAS | Lipid | CpG | chr_hg38 | Start_hg38 | Nearby genes | Population | Effect | SE | P | Directions (EA/AA) | I2 | Phet |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Exposure | HDL | cg27324117 | chr4 | 153793134 | NA | EA | − 0.0025 | 0.0005 | 2.11E−07 | |||
| AA | − 0.0016 | 0.0012 | 0.20 | |||||||||
| Meta | − 0.0024 | 0.0004 | 8.71E−08 | −/− | 0 | 0.4765 | ||||||
| cg02443467 | chr10 | 47191407 | NA | EA | − 0.0022 | 0.0004 | 1.17E−07 | |||||
| AA | − 0.0016 | 0.0010 | 0.09 | |||||||||
| Meta | − 0.0021 | 0.0004 | 2.30E−08 | −/− | 0 | 0.5916 | ||||||
| cg07373304 | chr16 | 998982 | RP11-161M6.3 | EA | − 0.0021 | 0.0004 | 2.26E−07 | |||||
| AA | − 0.0044 | 0.0017 | 0.01 | |||||||||
| Meta | − 0.0023 | 0.0004 | 1.41E−08 | −/− | 36 | 0.2115 | ||||||
| TG | cg01082498 | chr11 | 68840756 | CPT1A | EA | − 0.0006 | 0.0001 | 1.24E−07 | ||||
| AA | − 0.0005 | 0.0007 | 0.48 | |||||||||
| Meta | − 0.0006 | 0.0001 | 7.23E−08 | −/− | 0 | 0.8322 | ||||||
| cg06004232 | chr16 | 11293335 | RMI2 | EA | 0.0003 | 6.09E−05 | 1.20E−07 | |||||
| AA | 0.0007 | 0.0003 | 0.04 | |||||||||
| Meta | 0.0003 | 0.0001 | 1.79E−08 | +/+ | 5.7 | 0.3032 | ||||||
| cg11686214 | chr19 | 58573616 | CENPBD1P1;MZF1;MZF1-AS1 | EA | 0.0006 | 0.0001 | 1.45E−07 | |||||
| AA | 0.0006 | 0.0006 | 0.24 | |||||||||
| Meta | 0.0006 | 0.0001 | 5.20E−08 | +/+ | 0 | 0.929 | ||||||
| Outcome | TG | cg23550429 | chr2 | 30797935 | CAPN13 | EA | − 40.3640 | 20.2715 | 0.05 | |||
| AA | − 14.9963 | 2.8360 | 3.37E−07 | |||||||||
| Meta | − 15.4833 | 2.8087 | 3.54E−08 | −/− | 34.9 | 0.2152 | ||||||
| cg03260858 | chr3 | 49103337 | QARS | EA | 20.1158 | 13.6051 | 0.14 | |||||
| AA | 38.5596 | 6.9392 | 9.14E−08 | |||||||||
| Meta | 34.7521 | 6.1816 | 1.89E−08 | +/+ | 31.4 | 0.2272 | ||||||
| cg20601481 | chr11 | 67288314 | ANKRD13D | EA | − 27.9673 | 10.8875 | 0.01 | |||||
| AA | − 37.6708 | 7.6983 | 2.10E−06 | |||||||||
| Meta | − 34.4364 | 6.2857 | 4.29E−08 | −/− | 0 | 0.4668 | ||||||
| cg19590858 | chr14 | 34540645 | EAPP;RP11-671J11.5 | EA | − 31.9752 | 9.1836 | 5.17E−04 | |||||
| AA | − 27.2994 | 6.6324 | 5.73E−05 | |||||||||
| Meta | − 28.9022 | 5.3768 | 7.64E−08 | −/− | 0 | 0.6798 | ||||||
| cg20433103 | chr17 | 63941062 | SCN4A | EA | 43.8451 | 13.1675 | 8.98E−04 | |||||
| AA | 36.7039 | 8.0731 | 9.67E−06 | |||||||||
| Meta | 38.6549 | 6.8825 | 1.95E−08 | +/+ | 0 | 0.6438 | ||||||
| cg07439166 | chr19 | 35902502 | AD000864.6;HCST;NFKBID | EA | − 51.5564 | 15.2318 | 7.37E−04 | |||||
| AA | − 34.0310 | 7.4137 | 8.01E−06 | |||||||||
| Meta | − 37.3876 | 6.666 | 2.04E−08 | −/− | 6.6 | 0.3009 |
chr_hg38 chromosome in GRCh38/hg38, Start_hg38 CpG start position in GRCh38/hg38, HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides, TC total cholesterol, EA survivors of European ancestry, AA survivors of African ancestry