Table 1.
The prevalence of dhfr and dhps SNPs in P. falciparum isolates from pregnant women and healthcare seeking adults in Ile-Ife, Southwest Nigeria
| Gene | Group | SNP | Wild type n (%) | Mutant type n (%) | Mixed type n (%) |
|---|---|---|---|---|---|
| Pfdhfr | Pregnant women | N51I | 0 (0) | 16 (100) | 0 (0) |
| C59R | 0 (0) | 16 (100) | 0 (0) | ||
| S108N | 0 (0) | 16 (100) | 0 (0) | ||
| I164L | 16 (100) | 0 (0) | 0 (0) | ||
| Community | N51I | 1 (1.7) | 56 (96.6) | 1 (1.7) | |
| C59R | 1 (1.7) | 56 (96.6) | 1 (1.7) | ||
| S108N | 0 (0) | 57 (98.3) | 1 (1.7) | ||
| I164L | 58 (100) | 0 (0) | 0 (0) | ||
| ALL | N51I | 1 (1.4) | 72 (97.2) | 1 (1.4) | |
| C59R | 1 (1.4) | 72 (97.2) | 1 (1.4) | ||
| S108N | 0 (0.0) | 73 (98.6) | 1 (1.4) | ||
| I164L | 74 (100.0) | 0 (0.0) | 0 (0.00) | ||
| Pfdhps | Pregnant women | I431V | 11 (61.1) | 6 (33.3) | 1 (5.6) |
| S436A | 8 (44.4) | 9 (50) | 1 (5.6) | ||
| A437G | 0 (0) | 18 (100) | 0 (0) | ||
| K540E | 18 (100) | 0 (0) | 0 (0) | ||
| A581G | 16 (88.8) | 1 (5.6) | 1 (5.6) | ||
| A613S | 13 (72.2) | 4 (22.2) | 1 (5.6) | ||
| Community | I431V | 22 (51.2) | 19 (44.2) | 2 (4.6) | |
| S436A | 17 (39.5) | 21 (48.8) | 5 (11.7) | ||
| A437G | 0 (0) | 43 (100) | 0 (0) | ||
| K540E | 43 (100) | 0 (0) | 0 (0) | ||
| A581G | 26 (60.5) | 14 (32.6) | 3 (6.9) | ||
| A613S | 18 (41.8) | 22 (51.1) | 3 (6.9) | ||
| All | I431V | 33 (54.1) | 25 (40.9) | 3 (4.9) | |
| S436A | 25 (41.0) | 30 (49.2) | 6 (9.8) | ||
| A437G | 0 (0.0) | 61 (100) | 0 (0.0) | ||
| K540E | 61 (100) | 0 (0.00) | 0 (0.0) | ||
| A581G | 42 (68.9) | 15 (24.6) | 4 (6.6) | ||
| A613S | 31 (50.8) | 26 (42.6) | 4 (6.6) |