Table 3.
Biomarker Association and Risk Prediction of Contrast-associated Acute Kidney Injury and Major Adverse Kidney Event.
| Biomarker | Preangiography |
Postangiography |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Unadjusted OR (95% CI) | Pvalue | AdjustedOR (95% CI)a | Pvalue | AUROC (95% CI) | UnadjustedOR (95% CI) | Pvalue | AdjustedOR (95% CI)a | Pvalue | AUROC (95% CI) | |
| Contrast-associated acute kidney injury | ||||||||||
| Urinary [TIMP-2]•[IGFBP7], (ng/mL)2/1000 | 0.53 (0.24-1.20) | 0.13 | 0.47 (0.20-1.12) | 0.09 | 0.58 (0.52-0.65) | 0.04 (<0.001-1.72) | 0.09 | 0.04 (<0.001-1.65) | 0.09 | 0.55 (0.49-0.61) |
| Log urine creatinine-indexed urinary [TIMP-2]•[IGFBP7], (ng/mL)2/1,000 mg/dL | 0.65 (0.47-0.90) | 0.009 | 0.59 (0.42-0.83) | 0.002 | 0.59 (0.52-0.67) | 0.68 (0.44-1.05) | 0.08 | 0.64 (0.40-1.02) | 0.06 | 0.55 (0.48-0.62) |
| Log plasma BNP, pg/mL | 1.10 (0.92-1.32) | 0.31 | 1.16 (0.95-1.42) | 0.14 | 0.53 (0.46-0.60) | 1.10 (0.90-1.35) | 0.35 | 1.17 (0.93-1.48) | 0.18 | 0.52 (0.44-0.60) |
| Serum troponin, ng/mL | 1.03 (0.97-1.09) | 0.32 | 1.04 (0.98-1.10) | 0.22 | 0.55 (0.48-0.62) | 1.05 (0.99-1.12) | 0.11 | 1.07 (1.00-1.14) | 0.04 | 0.52 (0.44-0.60) |
| Plasma hs-CRP, mg/L | 1.02 (0.96-1.09) | 0.48 | 1.02 (0.95-1.09) | 0.69 | 0.52 (0.43-0.61) | 1.06 (0.99-1.14) | 0.06 | 1.07 (1.00-1.16) | 0.04 | 0.57 (0.48-0.67) |
| Major adverse kidney events | ||||||||||
| Urinary [TIMP-2]•[IGFBP7], (ng/mL)2/1,000 | 1.16 (0.87-1.53) | 0.31 | 1.11 (0.83-1.48) | 0.49 | 0.56 (0.48-0.63) | 1.14 (0.66-1.98) | 0.64 | 1.05 (0.57-1.94) | 0.87 | 0.56 (0.48-0.64) |
| Log urine creatinine-indexed urinary [TIMP-2]•[IGFBP7], (ng/mL)2/1,000 mg/dL | 1.42 (1.05-1.92) | 0.02 | 1.25 (0.91-1.72) | 0.16 | 0.57 (0.48-0.66) | 1.61 (1.18-2.20) | 0.003 | 1.41 (1.004-1.97) | 0.05 | 0.60 (0.51-0.69) |
| Log plasma BNP, pg/mL | 1.57 (1.26-1.97) | <0.001 | 1.55 (1.26-1.97) | <0.001 | 0.67 (0.58-0.75) | 1.56 (1.24-1.96) | <0.001 | 1.51 (1.17-1.95) | 0.001 | 0.65 (0.56-0.73) |
| Serum troponin, ng/mL | 1.17 (1.06-1.28) | 0.001 | 1.16 (1.06-1.27) | 0.001 | 0.69 (0.62-0.76) | 1.15 (1.04-1.27) | 0.006 | 1.15 (1.05-1.26) | 0.003 | 0.65 (0.57-0.73) |
| Plasma hs-CRP, mg/L | 1.12 (1.04-1.20) | 0.002 | 1.12 (1.04-1.20) | 0.002 | 0.68 (0.58-0.78) | 1.14 (1.06-1.22) | <0.001 | 1.15 (1.07-1.24) | <0.001 | 0.68 (0.57-0.79) |
Abbreviations: AUROCs, area under the receiver operating characteristic curves; OR, odds ratio; CI, confidence interval; TIMP-2; tissue inhibitor of matrix metalloproteinase 2; IGFBP7, insulin growth factor binding protein 7; BNP, β natriuretic peptide; hs-CRP, high-sensitivity C-reactive protein
a
Adjusted for baseline eGFR and urinary albumin-creatinine ratio. Models were fitted in patients with fully available data.