FIGURE 5.
OAd-MSC TLR4−/− induces the activation of NFκB in the tumor. A, Schematic illustration of experimental design. B,In vitro expression of NFκB pathway detected by bioluminiscence in CMT64 NFκB-Luc tumor cells after coculture with OAd-MSC for 24 and 48 hours (n = 5). C,In vivo expression of NFκB pathway in the tumor at endpoint after treatment with PBS, OAd-MSC WT and OAd-MSC TLR4−/−. All images are displayed at the same bioluminescence scale. D,In vivo activation ratio of NFκB pathway in the tumor at different timepoints (n = 5).
