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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Curr Opin Nephrol Hypertens. 2022 Dec 23;32(2):134–140. doi: 10.1097/MNH.0000000000000866

FIGURE 1.

FIGURE 1.

Main signaling pathways mediated by Sortilin in the endothelial cell. aCDase, acid ceramidase; aSMase, acid sphingomyelinase; DAG, diacylglycerol; DCS, dihydroceramide synthase; DES, dihydroceramide desaturase; ER, endoplasmic reticulum; Gq, subunit q of G protein alpha; KDHR, 3-ketodihydrosphingosine reductase; NOX2, NADPH oxidase 2; PI3K, phosphatidylinositol 4,5-bisphosphate 3-kinase; PKCε, protein kinase C epsilon; PLC, phospholipase C; PYK2, protein tyrosine kinase 2 beta; ROS, reactive oxygen species; S1P, sphingosine 1 phosphate; S1PR3, type 3 sphingosine 1 phosphate receptor; SMase, sphingomyelinase; SPHK, sphingosine kinase; SPNS2, sphingolipid transporter 2; SPPase, S1P phosphatase; SPT, serine palmitoyltransferase.