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Preclinical and clinical investigations showing that Sortilin drives arterial hypertension. (a) Sortilin induces hypertension through a mechanism that involves sphingosine-1-phosphate (S1P) lysosphingolipid receptor 3 and/or gp91phox/NOX2. (b) Circulating Sortilin levels are greater in hypertensive patients with noncontrolled hypertension and correlate with S1P levels.
