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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Neurobiol Dis. 2022 Sep 29;174:105878. doi: 10.1016/j.nbd.2022.105878

Figure 4: Model of remodeling of cortico and thalamic terminals in parkinsonism.

Figure 4:

According to studies in unilaterally treated 6-OHDA treated mice, in the parkinsonian state thalamic neurons exert a more potent activation of iSPNs than in normal animals. This increase is mediated by PF connections onto ChINs, which activate, through acetylcholine release, presynaptic nicotinic receptors on PF terminals (from Tanimura et al. 2019)