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. 2023 Mar;384(3):353–362. doi: 10.1124/jpet.122.001419

Fig. 2.

Fig. 2.

Effects of pretreatments on self-administration dose-response curves rats that self-administered cocaine (A, D, G, J, M) or MDPV, separated by low- (B, E, H, K, N) and high-responder phenotype (C, F, I, L, O). A–C: pretreatments of the dopamine D2/D3/sigma receptor antagonist haloperidol (0.01–0.32 mg/kg). D–F: pretreatments of the dopamine D3 receptor partial agonist VK4-40 (3.2–32 mg/kg). G–I: pretreatments of the dopamine D3 receptor antagonist VK4-116 (3.2–32 mg/kg). J–L: pretreatments of the 5-HT2C receptor agonist CP-809,101 (0.32-5.6 mg/kg). M–O: pretreatments of the sigma receptor antagonist BD1063 (1–10 mg/kg). Ordinate: reinforcers obtained during each component. Abscissa: Food 1 and Food 2 refer to components when grain-based pellets were available. The numbers refer to dose of cocaine (left) and MDPV (center and right) expressed as mg/kg/infusion on a log scale. The shaded gray region represents mean ± S.E.M. responding under baseline conditions. Error bars represent ± S.E.M.