TABLE 1.
ID50, as measured by percent change in area under the curve. Doses reported in mg/kg (95% confidence intervals).
| Haloperidol | VK4-40 | VK4-116 | CP-809,101 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID50 | Food ID50 | Potency ratio | Drug ID50 | Food ID50 | Potency ratio | Drug ID50 | Food ID50 | Potency ratio | Drug ID50 | Food ID50 | Potency ratio | |
| High-responders | ||||||||||||
| All | 0.08 (0.06, 0.12) |
0.07 (0.05, 0.10) |
0.85 (0.77, 0.93) |
30.6 (21.4, 43.8) |
6.6 (5.1, 8.5) |
0.21 (0.19, 0.24) |
17.3 (9.3, 32) |
7.3 (3.9, 13.6) |
0.42 (0.42, 0.42) |
1.61 (0.99, 2.63) |
1.19 (0.88, 1.60) |
0.73 (0.60, 0.88) |
| Male | 0.06 (0.03, 0.12) |
0.04 (0.04, 0.05) |
0.71 (0.42, 1.19) |
25.7 (12.8, 51.6) |
4.3 (3.8, 4.9) |
0.17 (0.10, 0.30) |
6.2 (3.2, 12.2) |
2.6 (1.9, 3.7) |
0.42 (0.30, 0.59) |
1.04 (0.47, 2.28) |
1.42 (0.88, 2.28) |
1.45 (0.94, 2.25) |
| Female | 0.11 (0.08, 0.15) |
0.10 (0.08, 0.13) |
0.90 (0.84, 0.96) |
34.6 (24.9, 48.2) |
8.1 (6.4, 10.2)* |
0.23 (0.21, 0.26) |
35.9 (23.1, 55.9) * |
14.3 (8.2, 24.8)* |
0.40 (0.36, 0.44) |
2.35 (1.50, 3.68) |
1.00 (0.75, 1.33) |
0.42 (0.38, 0.45) |
| Low-responders | ||||||||||||
| All | 0.08 (0.05, 0.14) |
0.07 (0.03, 0.12) |
0.78 (0.69, 0.88) |
12.4 (7.0, 22.0) |
6.2 (0.37, 10.4) |
0.50 (0.47, 0.53) |
13.5 (8.1, 22.5) |
10.4 (6.6, 16.4) |
0.77 (0.73, 0.82) |
1.78 (1.09, 2.91) |
0.95 (0.64, 1.41) |
0.53 (0.48, 0.58) |
| Male | 0.09 (0.05, 0.19) |
0.05 (0.02, 0.14) |
0.55 (0.40, 0.77) |
8.3 (4.4, 15.9) |
4.9 (2.3, 10.8) |
0.59 (0.52, 0.68) |
8.1 (5.1, 12.9) |
7.2 (4.0, 12.7) |
0.88 (0.70, 0.99) |
1.16 (0.74, 1.83) |
0.81 (0.50, 1.30) |
0.63 (0.57, 0.69) |
| Female | 0.07 (0.04, 0.12) |
0.09 (0.07, 0.12) |
1.32 (0.97, 1.79) |
27.5 (14.4, 52.2) |
8.3 (4.9, 13.9) |
0.30 (0.31, 0.38) |
27.6 (14.8, 51.7) * |
18.3 (16.0, 21.0) |
0.66 (0.41, 1.08) |
3.53 (1.72, 7.25) |
1.22 (0.66, 2.24) |
0.34 (0.31, 0.38) |
| Cocaine | ||||||||||||
| All | 0.12 (0.08, 0.19) |
0.06 (0.03, 0.10) |
0.48 (0.45, 0.51) |
17.5 (11.7, 26.3) |
4.4 (2.7, 7.2) |
0.25 (0.23, 0.27) |
16.4 (10.4, 25.9) |
10.1 (0.65, 15.6) |
0.61 (0.60, 0.63) |
2.54 (1.81, 3.57) |
0.90 (0.61, 1.35) |
0.33 (0.31, 0.35) |
| Male | 0.07 (0.03, 0.13) |
0.03 (0.01, 0.08) |
0.50 (0.40, 0.62) |
9.6 (6.3, 14.6) |
6.8 (5.3, 8.8) |
0.71 (0.60, 0.84) |
10.7 (6.7, 17.1) |
9.0 (0.59, 13.6) |
0.84 (0.80, 0.88) |
1.53 (1.02, 2.29) |
0.89 (0.40, 1.98) |
0.58 (0.39, 0.86) |
| Female | 0.20 (0.15, 0.26) * |
0.09 (0.08, 0.11) |
0.46 (0.41, 0.51) |
28.8 (21.7, 38.4) * |
3.2 (1.6, 6.3) |
0.11 (0.08, 0.16) |
27.4 (15.5, 48.6) |
11.6 (5.2, 25.8) |
0.42 (0.34, 0.53) |
3.94 (3.14, 4.93) * |
0.92 (0.63, 1.33) |
0.20 (0.19, 0.21) |
| All groups | ||||||||||||
| Male | 0.07 (0.05, 0.11) |
0.04 (0.03, 0.04) |
0.56 (0.32, 0.70) |
11.9 (7.7, 18.2) |
5.2 (3.6, 7.6) |
0.44 (0.42, 0.46) |
8.3 (6.0, 11.4) |
6.1 (4.2, 8.8) |
0.73 (0.70, 0.77) |
1.22 (0.88, 1.69) |
0.99 (0.69, 1.42) |
0.78 (0.73, 0.84) |
| Female | 0.12 (0.09, 0.16) |
0.09 (0.08, 0.11) |
0.78 (0.67, 0.90) |
30.7 (24.4, 38.8) * |
6.2 (4.4, 8.8) |
0.20 (0.18, 0.23) |
30.7 (22.4, 42.1) * |
14.2 (9.9, 20.4)* |
0.46 (0.44, 0.48) |
3.16 (2.38, 4.20) * |
1.01 (0.79, 1.29) |
0.30 (0.29, 0.31) |
* Indicates non-overlapping confidence intervals compared with male rats in the same group.