CLR01 treatment reduces α-syn seeds in MSA mouse brain. (A) Examples of unseeded (top) and seeded (bottom) biosensor cells. (B) FRET analysis of seed content in the brain extracts’ soluble fraction. The error bars indicate SD. **p < 0.01, ****p < 0.0001 one-way ANOVA with post hoc Tukey test. (C) Linear regression analysis of the correlation between the seeding activity and the center/periphery ratio. This figure was published originally in BBA—Molecular Basis of Disease, 1865, M. Herrera-Vaquero, D. Bouquio, M. Kallab, K. Biggs, G. Nair, J. Ochoa, A. Heras-Garvina, C. Heid, I. Hadrovic, W. Poewe, G. K. Wenning, F.-G. Klärner, T. Schrader, G. Bitan, and N. Stefanova. The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy, 165513, Copyright Elsevier (2019).