Fig. 12.

CLR01 treatment reduces tau aggregation in the CA3 region of P301S-tau mice. Brain sections from P301S-tau mice were stained with Gallyas silver-stain. (A–C) Representative images of the hippocampus (top) and zooming on the CA3 region (bottom) are presented for the mice treated with 0 (A), 0.3 (B), or 1.0 (C) mg/Kg CLR01 and show black/dark brown cells containing aggregated tau. (D) The data were quantified as the number of tau-aggregate-containing cells per mm² in the CA3. The data are presented as mean ± SD. P values were calculated using a one-way ANOVA with post hoc Tukey test. This figure was published originally in BMC—Alzheimer’s Research and Therapy, 2021, J. Di, I. Siddique, Z. Li, G. Malki, S. Hornung, S. Dutta, I. Hurst, E. Eshaaya, A. Wang, S. Tu, A. Boghos, I. Ericsson, F.-G. Klärner, T. Schrader, and G. Bitan. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S- tau transgenic mice, Creative Commons Attribution 4.0 International License.