Fig. 19.
Brain-to-blood ratio of CLR01 following SC administration. OVX-SNCA mice were administered increasing doses of CLR01 spiked with 10% 3H-CLR01 (3.92 μCi/g body weight in the highest dose). Blood and brain were harvested at 1, 8, or 24 hours, digested in Solvable (Perkin-Elmer) and the radioactivity counted by scintillation. Brain-to-blood ratio (%) was calculated as cpm/g brain divided by cpm/mL blood ×100. Two wild-type littermates were included in the 8-hour group and are marked by red dots.