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. 2023 Mar;75(2):263–308. doi: 10.1124/pharmrev.122.000654

Scheme 5.

Scheme 5

Synthesis of water-soluble molecular MTs carrying in their central benzene unit two phosphate (CLR01), methanephosphonate (CLR02), sulfate (CLR04), or O-methylenecarboxylate groups (CLR05). Note the different number of charges and pK values.